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1. (WO2019065901) METHOD AND KIT FOR PREDICTING THERAPEUTIC EFFECTIVENESS OF CHEMOTHERAPY FOR DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS
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Pub. No.: WO/2019/065901 International Application No.: PCT/JP2018/036080
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
C12Q 1/6813 (2018.01) ,C12N 15/09 (2006.01) ,C12Q 1/6886 (2018.01) ,G01N 33/53 (2006.01)
[IPC code unknown for C12Q 1/6813]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
[IPC code unknown for C12Q 1/6886]
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
国立大学法人九州大学 KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION [JP/JP]; 福岡県福岡市東区箱崎六丁目10番1号 6-10-1, Hakozaki, Higashi-ku, Fukuoka-shi, Fukuoka 8128581, JP
Inventors:
宮脇 恒太 MIYAWAKI Kohta; JP
赤司 浩一 AKASHI Koichi; JP
前田 高宏 MAEDA Takahiro; JP
加藤 光次 KATO Koji; JP
Agent:
棚井 澄雄 TANAI Sumio; JP
松沼 泰史 MATSUNUMA Yasushi; JP
及川 周 OIKAWA Shu; JP
飯田 雅人 IIDA Masato; JP
Priority Data:
62/565,12329.09.2017US
Title (EN) METHOD AND KIT FOR PREDICTING THERAPEUTIC EFFECTIVENESS OF CHEMOTHERAPY FOR DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS
(FR) PROCÉDÉ ET KIT DE PRÉDICTION DE L'EFFICACITÉ THÉRAPEUTIQUE D'UNE CHIMIOTHÉRAPIE POUR DES PATIENTS ATTEINTS D'UN LYMPHOME DIFFUS À GRANDES CELLULES B
(JA) びまん性大細胞型B細胞リンパ腫患者における化学療法に対する治療効果を予測するための方法及びキット
Abstract:
(EN) A method for predicting the therapeutic effectiveness of chemotherapy for a diffuse large B-cell lymphoma patient, wherein the method contains at least one step selected from the group consisting of a step for measuring the expression of a T-cell marker in a specimen obtained from the patient, a step for measuring the expression of a macrophage marker or dendritic cell marker in a specimen obtained from the patient, and a step for measuring the expression of an interstitial cell marker in a specimen obtained from the patient; and a step for predicting, on the basis of the expression of this marker, the prognosis for the therapy.
(FR) L'invention concerne un procédé de prédiction de l'efficacité thérapeutique d'une chimiothérapie pour un patient atteint d'un lymphome diffus à grandes cellules B, le procédé contenant au moins une étape choisie dans le groupe constitué d'une étape de mesure de l'expression d'un marqueur de lymphocytes T dans un échantillon obtenu du patient, d'une étape de mesure de l'expression d'un marqueur de macrophages ou d'un marqueur de cellules dendritiques dans un échantillon obtenu du patient, et d'une étape de mesure de l'expression d'un marqueur de cellules interstitielles dans un échantillon obtenu du patient ; et une étape de prédiction, sur la base de l'expression de ce marqueur, du pronostic de la thérapie.
(JA) びまん性大細胞型B細胞リンパ腫患者における化学療法に対する治療効果を予測するための方法であって、前記患者から得た検体中のT細胞のマーカーの発現を測定する工程、前記患者から得た検体中のマクロファージ又は樹状細胞のマーカーの発現を測定する工程及び前記患者から得た検体中の間質細胞のマーカーの発現を測定する工程からなる群から選ばれる少なくとも一つの工程と、前記マーカーの発現に基づき、前記治療による予後を予測する工程と、を含む方法。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)