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1. (WO2019065794) ANALGESIC DRUG USING PAC1 RECEPTOR ANTAGONISTIC DRUG
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Pub. No.: WO/2019/065794 International Application No.: PCT/JP2018/035831
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
C07D 471/04 (2006.01) ,A61K 31/4178 (2006.01) ,A61K 31/519 (2006.01) ,A61P 25/04 (2006.01) ,A61P 25/06 (2006.01) ,A61P 29/02 (2006.01) ,A61P 43/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4178
not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
04
Centrally acting analgesics, e.g. opioids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
06
Antimigraine agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
02
without antiinflammatory effect
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
国立大学法人鹿児島大学 KAGOSHIMA UNIVERSITY [JP/JP]; 鹿児島県鹿児島市郡元一丁目21番24号 21-24, Korimoto 1-chome, Kagoshima-shi, Kagoshima 8908580, JP
国立大学法人富山大学 NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA [JP/JP]; 富山県富山市五福3190 3190, Gofuku, Toyama-shi, Toyama 9308555, JP
学校法人昭和大学 SHOWA UNIVERSITY [JP/JP]; 東京都品川区旗の台一丁目5番8号 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 1428555, JP
Inventors:
栗原 崇 KURIHARA Takashi; JP
高▲崎▼ 一朗 TAKASAKI Ichiro; JP
豊岡 尚樹 TOYOOKA Naoki; JP
合田 浩明 GOUDA Hiroaki; JP
Agent:
特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES; 東京都港区愛宕二丁目5-1 愛宕グリーンヒルズMORIタワー32階 Atago Green Hills MORI Tower 32F, 5-1, Atago 2-chome, Minato-ku, Tokyo 1056232, JP
Priority Data:
2017-18644727.09.2017JP
Title (EN) ANALGESIC DRUG USING PAC1 RECEPTOR ANTAGONISTIC DRUG
(FR) MÉDICAMENT ANALGÉSIQUE UTILISANT UN MÉDICAMENT ANTAGONISTE DU RÉCEPTEUR PAC1
(JA) PAC1受容体拮抗薬を用いた鎮痛薬
Abstract:
(EN) The present invention relates to an analgesic drug containing: a compound represented by formula (I) or (II) (where, R1 is a C1-6-alkoxy group or a C1-6-haloalkoxy group; R2 is a hydrogen atom; R is an indazolyl group substituted with a halogen atom, a substituted or unsubstituted phenyl group, a pyrazolyl group, or a substituted or unsubstituted aralkyl group.); a salt thereof; or a solvate thereof.
(FR) La présente invention concerne un médicament analgésique contenant : un composé représenté par la formule (I) ou (II) (où R1 représente un groupe alcoxy en C1-6 ou un groupe halogénoalcoxy en C1-6 ; R2 représente un atome d'hydrogène ; R représente un groupe indazolyle substitué par un atome d'halogène, un groupe phényle substitué ou non substitué, un groupe pyrazolyle, ou un groupe aralkyle substitué ou non substitué) ; un sel de celui-ci ; ou un solvate de celui-ci.
(JA) 本発明は、次式(I)又は(II):(式中、RはC1-6-アルコキシ基又はC1-6-ハロアルコキシ基であり;Rは水素原子であり;Rはハロゲン原子で置換されたインダゾリル基、置換又は無置換のフェニル基、ピラゾリル基、又は置換又は無置換のアラルキル基である。) で示される化合物もしくはその塩又はそれらの溶媒和物を含有する鎮痛薬に関する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)