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1. (WO2019065774) RADIOACTIVE DRUG
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Pub. No.: WO/2019/065774 International Application No.: PCT/JP2018/035786
Publication Date: 04.04.2019 International Filing Date: 26.09.2018
IPC:
C07K 5/00 (2006.01) ,A61K 51/08 (2006.01) ,A61P 35/00 (2006.01) ,C07K 7/00 (2006.01) ,G01T 1/161 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
G PHYSICS
01
MEASURING; TESTING
T
MEASUREMENT OF NUCLEAR OR X-RADIATION
1
Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
16
Measuring radiation intensity
161
Applications in the field of nuclear medicine, e.g. in vivo counting
Applicants:
国立大学法人 千葉大学 NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY [JP/JP]; 千葉県千葉市稲毛区弥生町1番33号 1-33, Yayoi-cho, Inage-ku, Chiba-shi, Chiba 2638522, JP
Inventors:
荒野 泰 ARANO, Yasushi; JP
上原 知也 UEHARA, Tomoya; JP
鈴木 博元 SUZUKI, Hiroyuki; JP
Agent:
平澤 賢一 HIRASAWA, Kenichi; JP
佐々木 渉 SASAKI, Wataru; JP
Priority Data:
2017-18548426.09.2017JP
Title (EN) RADIOACTIVE DRUG
(FR) MÉDICAMENT RADIOACTIF
(JA) 放射性薬剤
Abstract:
(EN) The present invention relates to a compound or the like which can be labeled with a wide variety of atoms, including atoms having a relatively large atomic radius, and which can give a radioactive drug with which accumulation in the kidneys can be reduced from an early stage of administration. The present invention includes: [1] a compound or the like represented by formula (1); [2] a compound or the like obtained by bonding a target molecule recognition element to a compound described in [1]; [3] a metal complex compound or the like having one type of metal selected from the group consisting of radioactive metals and radioactive atom-labeled metals, and the compound or the like described in [1] or [2] which are coordinated to the metal; [4] a drug for preparing a radioactive drug, which includes the compound or the like described in [1] or [2]; [5] a use for producing a radioactive drug of the compound or the like described in [1] or [2]; [6] a radioactive drug including the metal complex compound or the like described in [3]; [7] a radiotherapeutic agent including the metal complex or the like described in [3]; and [8] a radioactive diagnostic imaging agent or the like including the metal complex compound or the like described in [3].
(FR) La présente invention concerne un composé ou analogue qui peut être marqué avec un grand choix d'atomes, y compris des atomes ayant un rayon atomique relativement grand, et qui peut donner un médicament radioactif grâce auquel l'accumulation dans les reins peut être réduite par rapport à un stade précoce d'administration. La présente invention comprend : [1] un composé ou analogue représenté par la formule (1) ; [2] un composé ou analogue obtenu par la liaison d'un élément de reconnaissance de molécule cible à un composé décrit en [1] ; [3] un composé complexe métallique ou analogue comprenant un type de métal choisi dans le groupe constitué par les métaux radioactifs et les métaux marqués par des atomes radioactifs, et le composé ou analogue décrit en [1] ou [2] qui est coordonné au métal ; [4] un médicament permettant de préparer un médicament radioactif, qui comprend le composé ou analogue décrit en [1] ou [2] ; [5] une utilisation pour la production d'un médicament radioactif du composé ou analogue décrit en [1] ou [2] ; [6] un médicament radioactif comprenant le composé complexe métallique ou analogue décrit en [3] ; [7] un agent radiothérapeutique comprenant le complexe métallique ou analogue décrit en [3] ; et [8] un agent d'imagerie diagnostique radioactif ou analogue comprenant le composé complexe métallique ou analogue décrit en [3].
(JA) 比較的大きな原子半径を有する原子を含め多様な原子による標識が可能であり、腎臓への集積を投与早期から低減できる放射性薬剤が得られる化合物等に関する。 〔1〕式(1)で表される化合物等、〔2〕上記〔1〕に記載の化合物等に、標的分子認識素子を結合させてなる化合物等、〔3〕放射性金属及び放射性原子標識金属からなる群から選ばれる1種の金属と、前記金属に配位した〔1〕又は〔2〕に記載の化合物等と、を有する金属錯体化合物等、〔4〕上記〔1〕又は〔2〕に記載の化合物等を含む、放射性薬剤の調製用薬剤、〔5〕上記〔1〕又は〔2〕に記載の化合物等の放射性薬剤の製造のための使用、〔6〕上記〔3〕に記載の金属錯体化合物等を含む、放射性薬剤、〔7〕上記〔3〕に記載の金属錯体化合物等を含む放射線治療薬及び〔8〕上記〔3〕に記載の金属錯体化合物等を含む放射性画像診断薬。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)