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1. (WO2019065718) COMPOSITION FOR PREVENTION, ALLEVIATION, AND/OR TREATMENT OF HEAT STROKE
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Pub. No.: WO/2019/065718 International Application No.: PCT/JP2018/035650
Publication Date: 04.04.2019 International Filing Date: 26.09.2018
IPC:
A61K 31/352 (2006.01) ,A23K 20/121 (2016.01) ,A23L 33/10 (2016.01) ,A23L 33/105 (2016.01) ,A61K 36/752 (2006.01) ,A61P 3/00 (2006.01) ,A61P 43/00 (2006.01) ,A61K 131/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
[IPC code unknown for A23K 20/121][IPC code unknown for A23L 33/10][IPC code unknown for A23L 33/105]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
75
Rutaceae (Rue family)
752
Citrus, e.g. lime, orange or lemon
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
131
Containing or obtained from seeds, nuts, fruits or grains
Applicants:
学校法人東洋大学 TOYO UNIVERSITY [JP/JP]; 東京都文京区白山5丁目28番20号 28-20, Hakusan 5-chome, Bunkyo-ku, Tokyo 1128606, JP
Inventors:
加藤 和則 KATO Kazunori; JP
Agent:
特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES; 東京都港区愛宕二丁目5-1 愛宕グリーンヒルズMORIタワー32階 Atago Green Hills MORI Tower 32F, 5-1, Atago 2-chome, Minato-ku, Tokyo 1056232, JP
Priority Data:
2017-18434326.09.2017JP
Title (EN) COMPOSITION FOR PREVENTION, ALLEVIATION, AND/OR TREATMENT OF HEAT STROKE
(FR) COMPOSITION POUR LA PRÉVENTION, LE SOULAGEMENT ET/OU LE TRAITEMENT D'UN COUP DE CHALEUR
(JA) 熱中症の予防、軽減及び/又は治療のための組成物
Abstract:
(EN) The present application provides a composition for the prevention, alleviation, and/or treatment of cytotoxicity of cells such as vascular endothelial cells due to heat stroke or heat stress in a subject and/or adverse events associated with the production and release of fever-induced inflammatory cytokines from blood cells due to heat stress, the composition containing at least one substance selected from the group consisting of auraptene, tangeretin, and medium-chain fatty acids as an active ingredient.
(FR) La présente invention concerne une composition pour la prévention, le soulagement et/ou le traitement de la cytotoxicité de cellules telles que les cellules endothéliales vasculaires sous l'effet d'un coup de chaleur ou d'un stress thermique chez un sujet et/ou des effets indésirables associés à la production et à la libération de cytokines inflammatoires induites par la fièvre hors des globules sanguins sous l'effet d'un stress thermique, la composition contenant au moins une substance, choisie dans le groupe constitué de l'auraptène, de la tangérétine et des acides gras à chaîne moyenne, en tant que principe actif.
(JA) この出願は、オーラプテン、タンゲレチン及び中鎖脂肪酸からなる群から選択される少なくとも1つの物質を有効成分として含む、被験体において熱中症、或いは暑熱ストレスの負荷による血管内皮細胞等の細胞の細胞障害、及び/又は暑熱ストレスの負荷による血液細胞からの発熱誘発炎症性サイトカインの産生及び放出に伴う異常、を予防、軽減及び/又は治療するための組成物を提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)