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1. (WO2019065527) METHOD FOR DETECTING PROSTATE CANCER
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Pub. No.: WO/2019/065527 International Application No.: PCT/JP2018/035155
Publication Date: 04.04.2019 International Filing Date: 21.09.2018
IPC:
G01N 33/574 (2006.01) ,G01N 33/532 (2006.01) ,C07K 14/375 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
531
Production of immunochemical test materials
532
Production of labelled immunochemicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
37
from fungi
375
from Basidiomycetes
Applicants:
株式会社J-オイルミルズ J-OIL MILLS, INC. [JP/JP]; 東京都中央区明石町8番1号 8-1, Akashi-cho, Chuo-ku Tokyo 1040044, JP
国立大学法人大阪大学 OSAKA UNIVERSITY [JP/JP]; 大阪府吹田市山田丘1番1号 1-1, Yamadaoka, Suita-shi, Osaka 5650871, JP
Inventors:
藤田 和利 FUJITA Kazutoshi; JP
野々村 祝夫 NONOMURA Norio; JP
三善 英知 MIYOSHI Eiji; JP
小林 夕香 KOBAYASHI Yuka; JP
Agent:
中嶋 伸介 NAKAJIMA Shinsuke; JP
Priority Data:
2017-19150529.09.2017JP
Title (EN) METHOD FOR DETECTING PROSTATE CANCER
(FR) MÉTHODE DE DÉTECTION DU CANCER DE LA PROSTATE
(JA) 前立腺癌の検出方法
Abstract:
(EN) [Problem] To provide a method for detecting prostate cancer, the method having a higher degree of certainty than the PSA blood test and providing measurement values that correlate with risk classification. [Solution] This method for detecting prostate cancer is characterized in that: the method includes reacting fucose α1→6 specific lectin and fucosylated PSA contained in a sample constituted of serum collected from a subject, and detecting the reacted lectin; and the pH in at least one step of a group of steps consisting of the reaction step for reacting the fucosylated PSA and the lectin and processing steps thereafter is adjusted to above 8.5 and less than 11.0.
(FR) Le problème décrit par la présente invention est de fournir une méthode de détection du cancer de la prostate, la méthode présentant un degré de certitude plus élevé que le test sanguin de l'APS et fournissant des valeurs de mesure en corrélation avec une classification de risque. La solution selon l'invention porte sur une méthode de détection du cancer de la prostate consistant : à faire réagir de la lectine spécifique du fucose α1→6 et un PSA fucosylé contenu dans un échantillon constitué de sérum prélevé chez un sujet, et à détecter la lectine amenée à réagir ; et à ajuster le pH, pendant l'étape de réaction du PSA fucosylé et de la lectine et/ou pendant les étapes de traitement ultérieures, au-dessus de 8,5 et au-dessous de 11,0.
(JA) 【課題】血中PSA検査よりも確度が高く、そして測定値がリスク分類と相関するような前立腺癌の検出方法を提供する。 【解決手段】本発明の前立腺癌の検出方法は、被験者から採取された血清からなる検体に含まれるフコシル化PSAと、フコースα1→6特異的レクチンとを反応させ、反応した前記レクチンを検出することを含み、前記フコシル化PSAと前記レクチンとの反応工程及びそれ以降の処理工程からなる工程群の少なくとも一工程のpHを8.5よりも高く、11.0未満に調整することを特徴とする。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)