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1. (WO2019064863) PRODUCTION METHOD FOR 1,2,2,2-TETRAFLUOROETHYL DIFLUOROMETHYL ETHER (DESFLURANE)
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Pub. No.: WO/2019/064863 International Application No.: PCT/JP2018/027796
Publication Date: 04.04.2019 International Filing Date: 25.07.2018
IPC:
C07C 41/22 (2006.01) ,C07C 43/12 (2006.01) ,C07B 61/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
41
Preparation of ethers; Preparation of compounds having groups, groups or groups
01
Preparation of ethers
18
by reactions not forming ether-oxygen bonds
22
by introduction of halogen; by substitution of halogen atoms by other halogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
43
Ethers; Compounds having groups, groups or groups
02
Ethers
03
having all ether-oxygen atoms bound to acyclic carbon atoms
04
Saturated ethers
12
containing halogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61
Other general methods
Applicants:
セントラル硝子株式会社 CENTRAL GLASS COMPANY, LIMITED [JP/JP]; 山口県宇部市大字沖宇部5253番地 5253, Oaza Okiube, Ube-shi, Yamaguchi 7550001, JP
Inventors:
細井 健史 HOSOI, Kenji; JP
渡辺 峰男 WATANABE, Mineo; JP
Agent:
小林 博通 KOBAYASHI, Hiromichi; JP
富岡 潔 TOMIOKA, Kiyoshi; JP
山口 幸二 YAMAGUCHI, Koji; JP
Priority Data:
2017-19020229.09.2017JP
Title (EN) PRODUCTION METHOD FOR 1,2,2,2-TETRAFLUOROETHYL DIFLUOROMETHYL ETHER (DESFLURANE)
(FR) PROCÉDÉ DE PRODUCTION D'ÉTHER 1,2,2,2-TÉTRAFLUOROÉTHYL DIFLUOROMÉTHYLE (DESFLURANE)
(JA) 1,2,2,2-テトラフルオロエチルジフルオロメチルエーテル(デスフルラン)の製造方法
Abstract:
(EN) Provided is a method for efficiently producing high-purity 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane) using a fluorinating agent having excellent handleability. In a liquid phase, 1,2,2,2-tetrafluoroethyl dichloromethyl ether is subjected to a two-stage fluorination reaction. Thus, 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane) can be efficiently obtained while inhibiting side reactions.
(FR) L'invention concerne un procédé de production efficace d'éther 1,2,2,2-tétrafluoroéthyl difluorométhyle (desflurane) de grande pureté à l'aide d'un agent de fluoration ayant une excellente maniabilité. Dans une phase liquide, l'éther 1,2,2,2-tétrafluoroéthyl dichlorométhyle est soumis à une réaction de fluoration en deux étapes. Selon l'invention, l'éther 1,2,2,2-tétrafluoroéthyl difluorométhyle (desflurane) peut être obtenu de manière efficace tout en inhibant des réactions secondaires.
(JA) 高純度な1,2,2,2-テトラフルオロエチルジフルオロメチルエーテル(デスフルラン)を、取り扱いに優れたフッ素化剤を用いて、効率よく製造する方法を提供する。1,2,2,2-テトラフルオロエチルジクロロメチルエーテルに対し、液相中、2段階のフッ素化反応を行うことにより、副反応を抑制しながら効率的に1,2,2,2-テトラフルオロエチルジフルオロメチルエーテル(デスフルラン)を得ることが可能である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)