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1. (WO2019064184) PROCESS FOR PREPARATION OF SIPONIMOD, ITS SALTS AND SOLID STATE FORMS THEREOF
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Pub. No.: WO/2019/064184 International Application No.: PCT/IB2018/057424
Publication Date: 04.04.2019 International Filing Date: 26.09.2018
IPC:
A61K 31/397 (2006.01) ,C07D 205/04 (2006.01) ,C07D 251/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
397
having four-membered rings, e.g. azetidine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
205
Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
251
Heterocyclic compounds containing 1,3,5-triazine rings
02
not condensed with other rings
12
having three double bonds between ring members or between ring members and non-ring members
26
with only hetero atoms directly attached to ring carbon atoms
40
Nitrogen atoms
48
Two nitrogen atoms
Applicants:
DR. REDDY'S LABORATORIES LIMITED [IN/IN]; 8-2-337, Road No. 3, Banjara Hills, Telangana Hyderabad 500034, IN
Inventors:
ORUGANTI, Srinivas; IN
CHINTADA, Krishnarao; IN
KANDAGATLA, Bhaskar; IN
CHEERLAVANCHA, Raju; IN
MUDAPAKA, Vamsi Krishna; IN
VOGURI, Raja Sekhar; IN
THIPPARABOINA, Rajesh; IN
THIRUNAHARI, Satyanarayana; IN
Priority Data:
20174103423827.09.2017IN
20174103630312.10.2017IN
20184100788602.03.2018IN
20184101405912.04.2018IN
20184101771511.05.2018IN
Title (EN) PROCESS FOR PREPARATION OF SIPONIMOD, ITS SALTS AND SOLID STATE FORMS THEREOF
(FR) PROCÉDÉ DE PRÉPARATION DE SIPONIMOD, DE SES SELS ET DE FORMES À L'ÉTAT SOLIDE ASSOCIÉES
Abstract:
(EN) The present application provides process for preparation of siponimod, intermediates of siponimod, salts of siponimod, polymorphic forms and solid dispersions of siponimod and its salts thereof. The present application specifically provides crystalline polymorphic forms of siponimod base, siponimod hemifumarate and other salts and pharmaceutical compositions thereof. Also provided are solid dispersions of siponimod hemifumarate and pharmaceutical compositions containing them.
(FR) La présente invention concerne un procédé de préparation de siponimod, d'intermédiaires de siponimod, de sels de siponimod, de formes polymorphes et de dispersions solides de siponimod et de ses sels associés. La présente invention concerne spécifiquement des formes polymorphes cristallines de siponimod base, d'hémifumarate de siponimod et d'autres sels et compositions pharmaceutiques de ceux-ci. L'invention concerne également des dispersions solides d'hémifumarate de siponimod et des compositions pharmaceutiques les contenant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)