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1. (WO2019064125) INTEGRATED AUTOMATED FILTRATION FOR SEPARATION, WASHING AND DRYING OF PEPTIDE CRYSTALS
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Pub. No.: WO/2019/064125 International Application No.: PCT/IB2018/057204
Publication Date: 04.04.2019 International Filing Date: 19.09.2018
IPC:
C07K 14/62 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
62
Insulins
Applicants:
BIOCON LIMITED [IN/IN]; 20th KM, Hosur Road, Electronic City, Karnataka, Bangalore 560 100, IN
Inventors:
KANDUKURI, Sai, Srikar; IN
SHUKLA, Vibhava; IN
MARIMUTHU, Arul; IN
PATHY, Mukul; IN
HAZRA, Partha, P.; IN
Agent:
MAJUMDAR, Subhatosh; IN
GANGULI, Dr., Sanchita; IN
SEN, Abhishek; IN
VENKATESH, Mythili; IN
MAJUMDAR, Amrita; IN
KUNDU, Subarna; IN
CHAUBEY, Priyanka; IN
Priority Data:
20174103415826.09.2017IN
Title (EN) INTEGRATED AUTOMATED FILTRATION FOR SEPARATION, WASHING AND DRYING OF PEPTIDE CRYSTALS
(FR) FILTRATION AUTOMATISÉE INTÉGRÉE POUR LA SÉPARATION, LE LAVAGE ET LE SÉCHAGE DE CRISTAUX DE PEPTIDES
Abstract:
(EN) The present invention describes the integration of preparative crystallization, crystal separation, crystal washing and freeze-drying processes into single continuous process using pressure filtration. The process facilitates time reduction, and outlines the novel design of using multiple organic solvent washes and nitrogen gas purging for the removal of imbibed water and achieve final drug substance that meets the quality specifications.
(FR) La présente invention concerne l'intégration d'une cristallisation préparative, d'une séparation de cristaux, d'un lavage de cristaux et de procédés de lyophilisation en un seul procédé continu à l'aide d'une filtration sous pression. Le procédé contribue à la réduction du temps et définit la nouvelle conception d'utilisation de lavages par de multiples solvants organiques et de purge à l'azote gazeux pour éliminer l'eau imbibée et obtenir une substance médicamenteuse finale répondant aux spécifications de qualité.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)