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1. (WO2019064073) USE OF CA125 TO PREDICT ANTI-MESOTHELIN TREATMENT OF MESOTHELIOMAS
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Pub. No.: WO/2019/064073 International Application No.: PCT/IB2018/001206
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
G01N 33/574 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10 Koishikawa, 4-chome Bunkyo-ku, Tokyo, 112-8088, JP
Inventors:
KLINE, James, Bradford; US
NOCOLAIDES, Nicholas, C.; US
WANG, Wenquan; US
SOMERS, Elizabeth, B.; US
Priority Data:
62/564,15427.09.2017US
Title (EN) USE OF CA125 TO PREDICT ANTI-MESOTHELIN TREATMENT OF MESOTHELIOMAS
(FR) UTILISATION DE CA125 POUR PRÉDIRE LE TRAITEMENT ANTI-MÉSOTHÉLINE DE MÉSOTHÉLIOMES
Abstract:
(EN) Provided herein are methods of identifying and methods of treating a subpopulation of mesothelin-expressing cancer patients predicted to be responsive to treatment regimens including an anti-mesothelin therapeutic agent based on soluble CA125 levels and CA125 direct binding.
(FR) L'invention concerne des procédés d'identification et des procédés de traitement d'une sous-population de patients atteints d'un cancer exprimant la mésothéline prédits comme répondant à des régimes de traitement comprenant un agent thérapeutique anti-mésothéline sur la base de niveaux de CA125 solubles et d'une liaison directe à CA125.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)