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1. (WO2019064040) DEVICES AND METHODS FOR ANALYSIS OF MALE INFERTILITY
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Claims

What is claimed is:

1. A system for collection and analysis of a semen sample, the device comprising:

a receptacle; and

an analytical device attached to the receptacle, the analytical device comprising an optical device positioned to interrogate a portion of a semen sample in the receptacle and a processor configured to receive optical data from the optical device and determine sperm number, sperm morphology, and sperm motility of the semen sample.

2. The system of claim 1, wherein the receptacle is removable from the analytical device.

3. The system of claim 1, wherein the receptacle comprises a microfluidic element configured to receive the portion of the semen sample interrogated by the optical device.

4. The system of claim 3, wherein the optical device comprises a CMOS sensor

5. The system of claim 1, wherein the system comprises a pump operably coupled to the receptacle to transport the portion of the semen sample into the microfluidic element.

6. The system of claim 1, wherein the analytical device comprises a transmitter that is configured to transmit information about sperm number, sperm morphology, or sperm motility of the semen sample to a remote device.

7. The system of claim 1, wherein the analytical device comprises a lighting system.

8. The system of claim 7, wherein the lighting system comprises:

a light source; and

at least one optical fiber configured to transmit light from the light source to the receptacle.

9. The system of claim 7, wherein an interior surface of the receptacle comprises a reflective coating that reflects light from the lighting system to the portion of the semen sample interrogated by the optical device.

10. The system of claim 1, wherein an interior surface of the receptacle comprises a coating that prevents semen from adhering to the interior surface.

11. A receptacle for semen analysis comprising:

a macrofluidic fluidic chamber;

a chamber opening; and

a microfluidic element integrated into the chamber and in fluidic connection with an interior of the chamber such that the microfluidic element receives a portion of a semen sample from within the chamber, wherein the receptacle is configured to be held in a hand of a user.

12. The receptacle of claim 11, wherein the opening is dimensioned receive a portion of a penis with an air gap between the portion of the penis and the opening.

13. The receptacle of claim 11, wherein the opening comprises an elastomeric material.

14. The receptacle of claim 13, wherein the elastomeric material is selected from the group consisting of silicone, plastic, and rubber.

15. The receptacle of claim 11, wherein an interior surface of the macrofluidic fluidic chamber comprises a reflective coating.

16. The receptacle of claim 11, wherein an interior surface of the macrofluidic fluidic chamber comprises a coating that prevents semen from adhering to one or more walls of the macrofluidic fluidic chamber.

17. The receptacle of claim 11, further comprising a removable lid to cover the opening.

18. A method of analyzing a semen sample from a subject, the method comprising:

providing a device configured to be held in a hand of a user, the device comprising: a receptacle;

an optical element; and

a processor;

receiving a semen sample into the receptacle; and

determining sperm number, sperm morphology, and sperm motility information of the semen sample within the device via the optical element and processor, wherein the method is performed without any external sample preparation steps.

19. The method of claim 18, wherein the method is performed without transferring the semen sample outside of the device.

20. The method of claim 18, wherein the receptacle is configured to receive a portion of a penis.

21. The method of claim 18, further comprising transmitting the sperm number, the sperm morphology, and the sperm motility information of the semen sample to a remote device.

22. The method of claim 18, further comprising adding a viscosity-altering agent to the semen sample within the device.

23. The method of claim 18, wherein the method does not involve heating the semen sample.

24. The method of claim 18, wherein the receptacle is removable from the optical element and the processor.