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1. (WO2019064030) MODIFIED CAR-T
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Pub. No.: WO/2019/064030 International Application No.: PCT/GB2018/052801
Publication Date: 04.04.2019 International Filing Date: 01.10.2018
IPC:
C07K 14/705 (2006.01) ,C07K 14/725 (2006.01) ,C07K 14/735 (2006.01) ,C12N 5/0783 (2010.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
735
Fc receptors
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
Applicants:
TC BIOPHARM LIMITED [GB/GB]; Maxim 1 2 Parklands Way Holytown Motherwell ML1 4WR, GB
Inventors:
PATAKAS, Agapitos; GB
LONDON, Timothy; GB
COSIMO, Emilio; GB
Agent:
MURGITROYD & COMPANY; Scotland House 165-169 Scotland Street Glasgow Central Scotland G5 8PL, GB
Priority Data:
1715918.729.09.2017GB
Title (EN) MODIFIED CAR-T
(FR) RÉCEPTEUR D'ANTIGÈNE CHIMÈRE (CAR) MODIFIÉ
Abstract:
(EN) The present invention relates to gamma delta (γδ) T cells and / or Natural Killer (NK) cells expressing constructs to provide for the expression of a Chimeric Antigen Receptor (CAR) incorporating the signalling domain of FCY Receptors. Suitably the invention also relates to constructs to provide such CARs and methods for introducing such CARs into cells and expressing such CARs in cells comprising receptors of gamma delta (γδ) T cells and / or Natural Killer (NK) cells.
(FR) L'invention concerne des cellules T gamma-delta (γδ) et/ou des cellules tueuses naturelles (NK) exprimant des constructions destinées à l'expression d'un récepteur d'antigène chimère (CAR) incorporant le domaine de signalisation des récepteurs FCY. L'invention concerne également des constructions pouvant fournir de tels CAR et des procédés pouvant introduire de tels CAR dans des cellules et exprimer de tels CAR dans des cellules comprenant des récepteurs de cellules T gamma-delta (γδ) et/ou des cellules tueuses naturelles (NK).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)