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1. (WO2019064026) NEW PHARMACEUTICAL COMPOSITIONS
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Pub. No.: WO/2019/064026 International Application No.: PCT/GB2018/052792
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
A61K 9/08 (2006.01) ,A61K 31/485 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
485
Morphinan derivatives, e.g. morphine, codeine
Applicants:
OREXO AB [SE/SE]; PO Box 303 SE-751 05 Uppsala, SE
Inventors:
FISCHER, Andreas; SE
Agent:
MCNEENEY, Stephen Phillip; GB
Priority Data:
1715881.729.09.2017GB
1810265.722.06.2018GB
Title (EN) NEW PHARMACEUTICAL COMPOSITIONS
(FR) NOUVELLES COMPOSITIONS PHARMACEUTIQUES
Abstract:
(EN) There are provided pharmaceutically-acceptable dosage forms suitable for peroral administration to the gastrointestinal tract, which dosage forms comprise pharmaceutically-acceptable compositions in the form of a liquid, in which an opioid analgesic, such as buprenorphine, is dissolved in a solvent system comprising a C8-20 fatty acid that is a liquid at about 40°C, such as caprylic acid, capric acid, lauric acid, oleic acid or linoleic acid. The dosage forms are abuse-resistant and are useful in the treatment of inter alia opioid dependency/addiction and/or pain.
(FR) L'invention concerne des formes galéniques pharmaceutiquement acceptables appropriées pour une administration perorale dans le tractus gastro-intestinal, lesdites formes galéniques comprenant des compositions pharmaceutiquement acceptables sous la forme d'un liquide, dans lesquelles un analgésique opioïde, tel que de la buprénorphine, est dissous dans un système de solvant comprenant un acide gras en C8-20 qui est un liquide à environ 40 °C, tel que l'acide caprylique, l'acide caprique, l'acide laurique, l'acide oléique ou l'acide linoléique. Les formes galéniques empêchent un usage abusif et sont utiles dans le traitement, entre autres, de la dépendance/accoutumance aux opioïdes et/ou de la douleur.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)