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1. (WO2019063838) METHOD FOR TREATING CANCER WITH A COXSACKIEVIRUS B3 (CVB3) VARIANT
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Pub. No.: WO/2019/063838 International Application No.: PCT/EP2018/076624
Publication Date: 04.04.2019 International Filing Date: 01.10.2018
IPC:
A61K 35/768 (2015.01) ,C12N 7/08 (2006.01)
[IPC code unknown for A61K 35/768]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04
Inactivation or attenuation; Producing viral sub-units
08
by serial passage of virus
Applicants:
TECHNISCHE UNIVERSITÄT BERLIN [DE/DE]; Straße des 17. Juni 135 10623 Berlin, DE
Inventors:
FECHNER, Henry; DE
HAZINI, Ahmet; DE
BRÜCKNER, Vanessa; DE
Agent:
FLEUCHAUS, Andrea; DE
Priority Data:
15/720,85029.09.2017US
Title (EN) METHOD FOR TREATING CANCER WITH A COXSACKIEVIRUS B3 (CVB3) VARIANT
(FR) MÉTHODE DE TRAITEMENT DU CANCER AVEC UNE VARIANTE DU VIRUS COXSACKIE B3 (CVB3)
Abstract:
(EN) The present invention relates to a method for treating cancer in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a Coxsackie B3 group virus or a modified form thereof, wherein the cells of the cancer express a heparan sulfate (HS) receptor on their surface and the virus binds to said HS receptor, enters and accumulates in the cancer cells, whereby at least some cancer cells undergo viral lysis.
(FR) La présente invention concerne une méthode de traitement du cancer chez un sujet en ayant besoin, comprenant l'administration audit sujet d'une quantité thérapeutiquement efficace d'un virus du groupe Coxsackie B3 ou d'une forme modifiée de celui-ci, les cellules du cancer exprimant un récepteur sulfate d'héparane (HS) sur leur surface et le virus se liant audit récepteur HS, entrant et s'accumulant dans les cellules cancéreuses, moyennant quoi au moins certaines cellules cancéreuses subissent une lyse virale.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)