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1. (WO2019063803) CLICK BASED LIGATION
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Pub. No.: WO/2019/063803 International Application No.: PCT/EP2018/076495
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
C07H 1/00 (2006.01) ,C07H 21/02 (2006.01) ,C07H 21/04 (2006.01) ,C12Q 1/6844 (2018.01) ,C12Q 1/6855 (2018.01) ,C12Q 1/686 (2018.01) ,C12Q 1/6874 (2018.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1
Processes for the preparation of sugar derivatives
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02
with ribosyl as saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
[IPC code unknown for C12Q 1/6844][IPC code unknown for C12Q 1/6855][IPC code unknown for C12Q 1/686][IPC code unknown for C12Q 1/6874]
Applicants:
BASECLICK GMBH [DE/DE]; Floriansbogen 2-4 82061 Neuried, DE
Inventors:
FRISCHMUTH, Thomas; DE
SERDJUKOW, Sascha; DE
Agent:
WEICKMANN & WEICKMANN PARTMBB; Postfach 860 820 81635 München, DE
Priority Data:
17194093.529.09.2017EP
18164071.526.03.2018EP
Title (EN) CLICK BASED LIGATION
(FR) LIGATURE BASÉE SUR UNE RÉACTION « CLICK »
Abstract:
(EN) The present invention relates to new methods and reagents for coupling molecules by a so-called click reaction in the presence of a suitable catalyst and a metal cation. Further, the invention relates to an activator composition for such click ligation reaction, a click ligation reagent kit, a device for performing such click ligation reaction, and the use of such method, composition, reagent kit and device to improve the efficiency of coupling of molecules via a click reaction, especially in the context of next generation nucleic acid sequencing methods.
(FR) La présente invention concerne de nouveaux procédés et réactifs permettant le couplage de molécules par une réaction dite « click » en présence d'un catalyseur approprié et d'un cation métallique. L'invention concerne en outre une composition d'activateur pour une telle réaction de ligature de type click, un kit de réactif de ligature de type click, un dispositif pour réaliser une telle réaction de ligature de type click, et l'utilisation d'un tel procédé, composition, kit de réactif et dispositif pour améliorer l'efficacité de couplage de molécules par l'intermédiaire d'une réaction de type click, en particulier dans le domaine des procédés de séquençage d'acide nucléique de nouvelle génération.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)