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1. (WO2019063756) INFLAMMATORY BIOMARKERS FOR PREDICTING RESPONSIVENESS TO FGF-18 COMPOUND
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Pub. No.: WO/2019/063756 International Application No.: PCT/EP2018/076391
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
G01N 33/68 (2006.01) ,A61K 31/00 (2006.01) ,A61K 38/18 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
Applicants:
MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt, DE
Inventors:
LADEL, Christoph H.; DE
GUEHRING, Hans; DE
BAY-JENSEN, Anne-Christine; DK
KARSDAL, Morten; DK
QVIST, Per; DK
Agent:
MERCK SERONO S.A.; Terre Bonne Business Park A2 Route de Crassier 15 1262 Eysins, CH
Priority Data:
17194169.329.09.2017EP
18169317.725.04.2018EP
Title (EN) INFLAMMATORY BIOMARKERS FOR PREDICTING RESPONSIVENESS TO FGF-18 COMPOUND
(FR) BIOMARQUEURS INFLAMMATOIRES POUR PRÉDIRE LA RÉACTIVITÉ À UN COMPOSÉ FGF-18
Abstract:
(EN) The present invention relates to biomarkers associated with the clinical response to an FGF-18 compound before or during treatment of a cartilage disorder. It relates more particularly to specific proteins present in the blood, serum, synovial fluid or in the urine, which can be used as biomarkers for the diagnosis, pre-treatment of patients and during therapy of cartilage disorders. The invention can be used in predicting the response to an FGF-18 compound treatment, before starting the treatment or during the treatment. It could be used for selecting/identifying subjects to be treated according to specific doses and/or dosing regimens by intra-articular administration of an FGF-18 compound. The use of these biomarkers in diagnostics could result in increased benefit and reduced risk-benefit ratio in subjects.
(FR) La présente invention concerne des biomarqueurs associés à la réponse clinique à un composé FGF-18 avant ou pendant le traitement d'un trouble du cartilage. L'invention concerne plus particulièrement des protéines spécifiques présentes dans le sang, le sérum, le liquide synovial ou dans l'urine, qui peuvent être utilisées en tant que biomarqueurs pour le diagnostic, le prétraitement de patients et pendant la thérapie de troubles du cartilage. L'invention peut être utilisée pour prédire la réponse à un traitement de composé FGF-18, avant de démarrer le traitement ou pendant le traitement. L'invention peut être utilisée pour sélectionner/identifier des sujets à traiter selon des doses et/ou schémas posologiques spécifiques par administration intra-articulaire d'un composé FGF-18. L'utilisation de ces biomarqueurs dans des diagnostics pourrait conduire à un bénéfice accru et à un rapport risque-bénéfice réduit chez des sujets.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)