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1. (WO2019063705) CASTRATION RESISTANT PROSTATE CANCER
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Pub. No.: WO/2019/063705 International Application No.: PCT/EP2018/076293
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
C07K 5/02 (2006.01) ,C07K 7/06 (2006.01) ,A61K 47/60 (2017.01) ,A61K 47/54 (2017.01) ,A61P 35/00 (2006.01) ,A61K 47/56 (2017.01) ,A61K 47/68 (2017.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02
containing at least one abnormal peptide link
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
[IPC code unknown for A61K 47/60][IPC code unknown for A61K 47/54]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
[IPC code unknown for A61K 47/56][IPC code unknown for A61K 47/68]
Applicants:
TARGIMMUNE THERAPEUTICS AG [CH/CH]; Hochbergerstrasse 60c 4057 Basel, CH
Inventors:
POMBO-VILLAR, Esteban; CH
LEVITZKI, Alexander; IL
LANGUT, Yael; IL
ZIGLER, Maya; CH
SHIR, Alexei; IL
KITAS, Eric; CH
Agent:
SPERRLE, Martin; CH
Priority Data:
17193577.827.09.2017EP
17201728.714.11.2017EP
Title (EN) CASTRATION RESISTANT PROSTATE CANCER
(FR) CANCER DE LA PROSTATE RÉSISTANT À LA CASTRATION
Abstract:
(EN) The present invention relates to a polyplex for use in the treatment of castration resistant prostate cancer (CRPC) comprising a double stranded RNA (dsRNA) and a polymeric conjugate, wherein said polymeric conjugate consists of a linear polyethyleneimine (LPEl), one or more polyethylene glycol (PEG) moieties, one or more linkers and one or more targeting moieties, wherein said LPEl is covalently bound to one or more PEG moieties and each of said one or more PEG moieties is conjugated via one of the one or more linkers to one of the one or more targeting moieties, wherein each of said one or more targeting moieties is capable of binding to a cancer antigen, and wherein said cancer antigen is prostate surface membrane antigen (PSMA). Further, the invention relates to a pharmaceutical composition for use in the treatment of CRPC.
(FR) La présente invention concerne un polyplexe destiné à être utilisé dans le traitement du cancer de la prostate résistant à la castration (CRPC) comprenant un ARN double brin (dsRNA) et un conjugué polymère, ledit conjugué polymère étant constitué d'une polyéthylèneimine linéaire (LPEl), d'une ou de plusieurs fractions de polyéthylène glycol (PEG), un ou plusieurs lieurs et une ou plusieurs fractions de ciblage, ledit LPEl étant lié de manière covalente à une ou plusieurs fractions PEG et chacune desdites fractions PEG étant conjuguée par l'intermédiaire de tout lieur à toute fraction de ciblage, chacune desdites fractions de ciblage étant capable de se lier à un antigène cancéreux, et ledit antigène cancéreux étant un antigène membranaire de surface de la prostate (PSMA). La présente invention concerne également une composition pharmaceutique destinée à être utilisée dans le traitement du CRPC.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)