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1. (WO2019063581) NEW THERAPY FOR OSTEOARTHRITIC PAIN



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2018/076049 P 17/232 WO/PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
26 September 2018 27 September 2017
Applicant
MERCK PATENT GMBH
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 33/14 (2006.01)i; A61K 33/42 (2006.01)i; A61P 19/02 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS, EMBASE

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
T PHAM, "Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis", ANNALS OF THE RHEUMATIC DISEASES,Vol. 63, No. 12, 01 December 2004 (2004-12-01), page 1611-1617,
XP055456775
1-12
the whole document
(2)
X
F. NAVARRO-SARABIA ET AL, "A 40-month multicentre, randomised placebo-controlled study to assess the efficacy and carry-over effect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project", ANNALS OF THE RHEUMATIC DISEASES,Vol. 70, No. 11, 01 November 2011 (2011-11-01), page 1957-1962,
XP055456713
1-12
the whole document
(3)
X
ALTMAN R D ET AL, "A Double-Blind, Randomized, Saline-Controlled Study of the Efficacy and Safety of EUFLEXXA<(>R) for Treatment of Painful Osteoarthritis of the Knee, With an Open-Label Safety Extension (The FLEXX Trial)", 01 August 2009 (2009-08-01), Vol. 39, No. 1, page 1-9,
XP026374473
[retrieved on  2009-06-17]
1-4,7-12
the whole document
(4)
X
J. KARLSSON ET AL, "Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis. A controlled, randomized, double-blind, parallel-design multicentre study", RHEUMATOLOGY,Vol. 41, No. 11, 01 November 2002 (2002-11-01), page 1240-1248,
XP055266113
1-4,7-12
the whole document
(5)
X
BALTZER A W A ET AL, "Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis", 01 February 2009 (2009-02-01), Vol. 17, No. 2, page 152-160,
XP026018519
[retrieved on  2008-07-31]
1-4,7-12
the whole document
(6)
X
JUBB R W; PIVA S; BEINAT L; DACRE J; GISHEN P, "A one-year, randomised, placebo (saline) controlled clinical trial of 500-730 kDa sodium hyaluronate (Hyalgan) on the radiological change in osteoarthritis of the knee", INTERNATIONAL JOURNAL OF CLINICAL PRACTICE ENGLAND,Vol. 57, No. 6, July 2003 (2003-07), page 467-474,
XP009503946
1-12
the whole document
(7)
A
SALTZMAN BRYAN M ET AL, "The Therapeutic Effect of Intra-articular Normal Saline Injections for Knee Osteoarthritis: A Meta-analysis of Evidence Level 1 Studies", 27 December 2016 (2016-12-27), Vol. 45, No. 11, page 2647-2653,
XP009502590
[retrieved on  2016-12-27]
1-12
the whole document
(8)
A
ALTMAN ROY D ET AL, "Clinical benefit of intra-articular saline as a comparator in clinical trials of knee osteoarthritis treatments: A systematic review and meta-analysis of randomized trials", SEMINARS IN ARTHRITIS AND RHEUMATISM, ELSEVIER, AMSTERDAM, NL,Vol. 46, No. 2, 27 April 2016 (2016-04-27), page 151-159,
XP029741126
1-12
cited in the application
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
21 November 2018
Date of mailing of the international search report:
03 December 2018
Authorized officer:
Hoff, Philippe
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