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1. (WO2019063565) VIRAL ANTIGENS
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Pub. No.: WO/2019/063565 International Application No.: PCT/EP2018/076009
Publication Date: 04.04.2019 International Filing Date: 25.09.2018
IPC:
A61K 39/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
Applicants:
GLAXOSMITHKLINE BIOLOGICALS SA [BE/BE]; rue de l'Institut 89 1330 Rixensart, BE
Inventors:
BURNY, Wivine; BE
CASTADO, Cindy; BE
GIANNINI, Sandra; BE
MASSAUX, Julien; BE
Agent:
RACINE, Sophie; GB
Priority Data:
17193469.827.09.2017EP
Title (EN) VIRAL ANTIGENS
(FR) ANTIGÈNES VIRAUX
Abstract:
(EN) The present invention relates to RNA constructs capable of encoding antigenic peptides or polypeptides derived from multiple Human Papilloma Virus (HPV) early proteins, and to immunogenic compositions comprising such RNA constructs and a pharmaceutically acceptable carrier. Such RNA constructs and immunogenic compositions are useful in the treatment of persistent HPV infection and low-grade HPV lesions, particularly infections and lesions of human anogenital epithelial tissue,such as cervical epithelia.
(FR) La présente invention concerne des constructions d'ARN capables de coder pour des peptides ou polypeptides antigéniques dérivés de plusieurs protéines précoces des papillomavirus humains (PVH), et des compositions immunogènes comprenant de telles constructions d'ARN et un véhicule pharmaceutiquement acceptable. De telles constructions d'ARN et de telles compositions immunogènes sont utiles dans le traitement d'une infection à PVH persistante et de lésions à PVH de bas grade, en particulier des infections et des lésions du tissu épithélial anogénital humain, tel que l’épithélium cervical.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)