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1. (WO2019063097) RISK DETERMINATION FOR NEOPLASIA AND CANCER
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Pub. No.: WO/2019/063097 International Application No.: PCT/EP2017/074829
Publication Date: 04.04.2019 International Filing Date: 29.09.2017
IPC:
C12Q 1/6886 (2018.01)
[IPC code unknown for C12Q 1/6886]
Applicants:
ONCGNOSTICS GMBH [DE/DE]; Winzerlaer Str. 2 07745 Jena, DE
Inventors:
DÜRST, Matthias; DE
RUNNEBAUM, Ingo B.; DE
SCHMITZ, Martina; DE
HANSEL, Alfred; DE
Agent:
SCHNAPPAUF, Georg; DE
Priority Data:
Title (EN) RISK DETERMINATION FOR NEOPLASIA AND CANCER
(FR) DÉTERMINATION DU RISQUE DE NÉOPLASIE ET DE CANCER
Abstract:
(EN) Methods for the determination of the risk of developing neoplasia in a tissue, preferably anogenital tissue, showing no histopathological indications of neoplasia are described. The method is based on the determination of the methylation status of genomic DNA sequences associated with the genes ZNF671, ZNF154. ZNF776, ASTN1, BRINP2, DLX1, METAP1D and/or DLX2.
(FR) L'invention concerne des procédés de détermination du risque de développer une néoplasie dans un tissu, de préférence un tissu anogénital, ne présentant aucune indication histopathologique de la néoplasie. Le procédé se base sur la détermination de l'état de méthylation de séquences d'ADN génomique associées aux gènes ZNF671, ZNF154. ZNF776, ASTN1, BRINP2, DLX1, METAP1D et/ou DLX2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)