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1. (WO2019063018) ENGINEERED IMMUNE CELL HAVING SUICIDE GENE SWITCH AND TARGETING HUMAN MESOTHELIN
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/063018 International Application No.: PCT/CN2018/109134
Publication Date: 04.04.2019 International Filing Date: 30.09.2018
IPC:
C12N 5/10 (2006.01) ,C12N 15/867 (2006.01) ,A61K 35/17 (2015.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
亘喜生物科技(上海)有限公司 GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD. [CN/CN]; 中国上海市 徐汇区宜山路926号1幢12层 12th Floor, Building 1, 926 Yishan Road Xuhui District Shanghai 200233, CN
Inventors:
张华 ZHANG, Hua; CN
张永亮 ZHANG, Yongliang; CN
江鹏斐 JIANG, Pengfei; CN
刘丽萍 LIU, Liping; CN
杨春晖 YANG, Chunhui; CN
石欢 SHI, Huan; CN
马玲 MA, Ling; CN
何佳平 HE, Jiaping; CN
马安云 MA, Anyun; CN
沈连军 SHEN, Lianjun; CN
曹卫 CAO, Wei; CN
Agent:
上海一平知识产权代理有限公司 XU & PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room 106, Building No. 1 Universal High-Tech Plaza 958 Zhen Bei Road Putuo District, Shanghai 200333, CN
Priority Data:
201710916606.330.09.2017CN
Title (EN) ENGINEERED IMMUNE CELL HAVING SUICIDE GENE SWITCH AND TARGETING HUMAN MESOTHELIN
(FR) CELLULE IMMUNITAIRE MODIFIÉE AYANT UN COMMUTATEUR DE GÈNE SUICIDE ET CIBLANT LA MÉSOTHÉLINE HUMAINE
(ZH) 具有自杀基因开关的靶向人间皮素的工程化免疫细胞
Abstract:
(EN) Provided is a chimeric antigen receptor T cell targeting mesothelin, wherein the CAR structure of the cell comprises an apoptosis element, and PD1 gene expression in the cell is silenced. Also provided are a preparation comprising the cell, a use, and a kit for preparing the cell.
(FR) L'invention concerne un lymphocyte T récepteur d'antigène chimère ciblant la mésothéline, la structure CAR de la cellule comprenant un élément d'apoptose, et l'expression du gène PD1 dans la cellule étant silencieuse. L'invention concerne également une préparation comprenant la cellule, une utilisation et un kit de préparation de la cellule.
(ZH) 提供了一种靶向间皮素的嵌合抗原受体T细胞,该细胞的CAR结构中包含细胞自杀元件,并且细胞中的PD1基因表达是被沉默的。还提供了含有该细胞的制剂、用途以及用于制备细胞的试剂盒。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)