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1. (WO2019063002) CRYSTAL FORM OF BENVITIMOD, AND USE THEREOF AND PREPARATION METHOD THEREFOR
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Pub. No.: WO/2019/063002 International Application No.: PCT/CN2018/108990
Publication Date: 04.04.2019 International Filing Date: 30.09.2018
IPC:
C07C 39/21 (2006.01) ,C07C 37/84 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
39
Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
205
polycyclic, containing only six-membered aromatic rings as cyclic part, with unsaturation outside the rings
21
with at least one hydroxy group on a non-condensed ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
37
Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
68
Separation; Purification; Stabilisation; Use of additives
70
by physical treatment
84
by crystallisation
Applicants:
北京文丰天济医药科技有限公司 BEIJING WEN FENG TIANJI PHARMA CO., LTD. [CN/CN]; 中国北京市 昌平区中关村生命科学园生命园路8号院一区2号楼3层310室 Room 310, 3 Floor, 2 Building, Zone 1 No. 8, Life Garden Road, Zhongguancun Life Science Park Changping District, Beijing 102206, CN
Inventors:
陈庚辉 CHEN, Genhui; CN
李建雄 LI, Jianxiong; CN
Agent:
北京律智知识产权代理有限公司 BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD.; 中国北京市 朝阳区慧忠路5号B1605、B1606、B1607 B1605, B1606, B1607 No. 5 Huizhong Road, Chaoyang District Beijing 100101, CN
Priority Data:
201710915931.830.09.2017CN
Title (EN) CRYSTAL FORM OF BENVITIMOD, AND USE THEREOF AND PREPARATION METHOD THEREFOR
(FR) FORME CRISTALLINE DE BENVITIMOD, SON UTILISATION ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 苯烯莫德的晶型及其用途与制备方法
Abstract:
(EN) The present application relates to a crystal form of Benvitimod (i.e., the compound represented by formula I), a pharmaceutical composition having the crystal form, and a use thereof and a preparation method therefor.
(FR) La présente invention concerne une forme cristalline de benvitimod (c'est-à-dire, le composé représenté par la formule I), une composition pharmaceutique ayant la forme cristalline, ainsi qu'une utilisation de celle-ci et un procédé de préparation correspondant.
(ZH) 本申请涉及苯烯莫德(即式I所示化合物)的晶型、含有所述晶型的药物组合物及其用途和制备方法。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)