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1. (WO2019062876) FLUORESCENT PROBE, PREPARATION METHOD THEREFOR AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/062876 International Application No.: PCT/CN2018/108519
Publication Date: 04.04.2019 International Filing Date: 29.09.2018
IPC:
C09K 11/06 (2006.01) ,C07D 209/24 (2006.01) ,C07D 239/49 (2006.01) ,C07D 311/16 (2006.01) ,C07D 311/82 (2006.01) ,C07D 403/14 (2006.01) ,C07D 405/12 (2006.01) ,C07D 405/14 (2006.01) ,C07D 409/14 (2006.01) ,C07D 487/04 (2006.01) ,G01N 21/64 (2006.01)
C CHEMISTRY; METALLURGY
09
DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
K
MATERIALS FOR APPLICATIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
11
Luminescent, e.g. electroluminescent, chemiluminescent, materials
06
containing organic luminescent materials
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
18
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
24
with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46
Two or more oxygen, sulfur or nitrogen atoms
48
Two nitrogen atoms
49
with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
04
Benzo [b] pyrans, not hydrogenated in the carbocyclic ring
06
with oxygen or sulfur atoms directly attached in position 2
08
not hydrogenated in the hetero ring
16
substituted in position 7
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Ring systems having three or more relevant rings
80
Dibenzopyrans; Hydrogenated dibenzopyrans
82
Xanthenes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
62
Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63
optically excited
64
Fluorescence; Phosphorescence
Applicants:
华东理工大学 EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY [CN/CN]; 中国上海市 徐汇区梅陇路130号 No. 130 Meilong Road, Xuhui District Shanghai 200237, CN
Inventors:
朱麟勇 ZHU, Linyong; CN
杨弋 YANG, Yi; CN
鲍丙坤 BAO, Bingkun; CN
张晨霞 ZHANG, Chenxia; CN
张大生 ZHANG, Dasheng; CN
包春燕 BAO, Chunyan; CN
林秋宁 LIN, Qiuning; CN
李宁峰 LI, Ningfeng; CN
华鑫 HUA, Xin; CN
赵永亮 ZHAO, Yongliang; CN
刘韧玫 LIU, Renmei; CN
陈政达 CHEN, Zhengda; CN
孙玉莹 SUN, Yuying; CN
Agent:
上海翼胜专利商标事务所(普通合伙) SHANGHAI ESSEN PATENT & TRADEMARK OFFICE; 中国上海市 普陀区中山北路1958号2718室 Room 2718 No. 1958 Zhongshan N Rd., Putuo Shanghai 200063, CN
Priority Data:
201710909828.229.09.2017CN
Title (EN) FLUORESCENT PROBE, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) SONDE FLUORESCENTE, PROCÉDÉ DE PRÉPARATION ASSOCIÉ ET SON UTILISATION
(ZH) 一种荧光探针及其制备方法和用途
Abstract:
(EN) Provided are a fluorescent probe, a preparation method therefor and a use thereof. The fluorescent probe responds to viscosity sensitively and specifically, can be used for the specific fluorescence label of proteins, and can also be used in the quantification, detection or kinetic study of proteins and the imaging of cells, tissues and living bodies.
(FR) L'invention concerne une sonde fluorescente, un procédé de préparation associé et son utilisation. La sonde fluorescente répond à la viscosité de manière sensible et spécifique, peut être utilisée pour le marquage de fluorescence spécifique de protéines et peut également être utilisée dans la quantification, la détection ou l'étude cinétique de protéines et l'imagerie de cellules, de tissus et de corps vivants.
(ZH) 一种荧光探针及其制备方法和用途,所述荧光探针对粘度响应敏感并且特异,可用于蛋白的特异性荧光标记,还可用于蛋白的定量、检测或动力学研究以及细胞、组织和活体影像。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)