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1. (WO2019062872) DEUTERIUM-SUBSTITUTED CARBAZOLE COMPOUND
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Pub. No.: WO/2019/062872 International Application No.: PCT/CN2018/108428
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
C07D 209/86 (2006.01) ,C07D 209/88 (2006.01) ,A61K 31/403 (2006.01) ,A61P 31/00 (2006.01) ,A61P 33/00 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
80
[b, c]- or [b, d]-condensed
82
Carbazoles; Hydrogenated carbazoles
86
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
80
[b, c]- or [b, d]-condensed
82
Carbazoles; Hydrogenated carbazoles
88
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
成都中创蜀洋生物科技有限公司 CHENGDU SINNOCEAN BIOTECHNOLOGY CO., LTD. [CN/CN]; 中国四川省成都市 郫都区德源镇展望东路47号 No. 47, Zhanwang East Road, Deyuan Town, Pidu District, Chengdu, Sichuan 610000, CN
Inventors:
杨成 YANG, Cheng; CN
苏丹 SU, Dan; CN
钟治晖 ZHONG, Zhihui; CN
Agent:
成都高远知识产权代理事务所(普通合伙) GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP); 中国四川省成都市 高新区衣冠庙邮局A-42号信箱 The Yiguanmiao Post Office Box A-42, Hi-Tech Zone Chengdu, Sichuan 610041, CN
Priority Data:
201710922687.830.09.2017CN
Title (EN) DEUTERIUM-SUBSTITUTED CARBAZOLE COMPOUND
(FR) COMPOSÉ DE CARBAZOLE SUBSTITUÉ PAR DU DEUTÉRIUM
(ZH) 氘代咔唑类化合物
Abstract:
(EN) Disclosed is a deuterium-substituted carbazole compound, in particular a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof or a hydrate thereof. The compound of the present invention can be used to treat cancers, inflammation, microbial infectious diseases, viral infections and protozoal infections, and has a good application prospect.
(FR) L'invention concerne un composé de carbazole substitué par du deutérium, en particulier un composé tel que représenté par la formule (I) ou un sel pharmaceutiquement acceptable de celui-ci ou un hydrate dudit composé. Le composé selon la présente invention peut être utilisé pour traiter des cancers, une inflammation, des maladies infectieuses microbiennes, des infections virales et des infections protozoaires, et présente une bonne perspective d'application.
(ZH) 本发明公开了氘代咔唑类化合物,具体是式(Ⅰ)所示的化合物或其药学上可接受的盐或其水合物。本发明化合物可用于治疗癌症,炎症,微生物感染性疾病,病毒感染以及原生感染,应用前景优良。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)