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1. (WO2019062871) ANTI-EGF LIKE DOMAIN MULTIPLE 6 (EGFL6) ANTIBODIES AND THEIR APPLICATIONS IN CANCER DIAGNOSIS AND TREATMENT
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Pub. No.: WO/2019/062871 International Application No.: PCT/CN2018/108427
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
A61K 39/395 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/30 (2006.01) ,C07K 16/22 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
22
against growth factors
Applicants:
TAIPEI MEDICAL UNIVERSITY [CN/CN]; 250 Wuxing Street Taipei City, Taiwan 110, CN
CHANGHUA CHRISTIAN MEDICAL FOUNDATION CHANGHUA CHRISTIAN HOSPITAL [CN/CN]; No.135, Nanxiao St., Changhua City Changhua Conuty, Taiwan 500, CN
TSAI, Keng-Chang [CN/CN]; CN
Inventors:
LEE, Yu-Ching; CN
PAN, Shiow-Lin; CN
HUANGFU, Wei-Chun; CN
HUANG, Tsui-Chin; CN
WEI, Po-Li; CN
HUANG, Han-Li; CN
CHENG, Chun-Chun; CN
HUANG, Cheng-Chiao; CN
TSAI, Keng-Chang; CN
YEH, Kun-Tu; CN
Agent:
LEE AND LI - LEAVEN IPR AGENCY LTD.; Unit 2202, Tower A, Beijing Marriott Center No. 7, Jian Guo Men South Avenue Beijing 100005, CN
Priority Data:
62/566,50901.10.2017US
Title (EN) ANTI-EGF LIKE DOMAIN MULTIPLE 6 (EGFL6) ANTIBODIES AND THEIR APPLICATIONS IN CANCER DIAGNOSIS AND TREATMENT
(FR) ANTICORPS ANTI-DOMAINE ANALOGUE À EGF MULTIPLE 6 (EGFL6) ET LEURS APPLICATIONS DANS LE DIAGNOSTIC ET LE TRAITEMENT DU CANCER
Abstract:
(EN) Provided are an anti-EGF like domain multiple 6 antibody (anti-EGFL6 antibody) and cancer detection (or diagnosis) and treatment using the anti-EGFL6 antibody. Further provided are a single-chain antibody fragments (scFv) and humanized antibody, which have ability in binding to EGFL6 and in inhibiting angiogenesis and cancer cell growth.
(FR) L'invention concerne un anticorps anti-domaine analogue à EGF multiple 6 (anticorps anti-EGFL6) et la détection (ou le diagnostic) et le traitement du cancer à l'aide de l'anticorps anti-EGFL6. L'invention concerne en outre des fragments d'anticorps à chaîne unique (scFv) et un anticorps humanisé, qui ont la capacité de se lier à EGFL6 et d'inhiber l'angiogenèse et la croissance des cellules cancéreuses.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)