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1. (WO2019062848) N-(SUBSTITUTED SULFONYL)BENZAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF
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Pub. No.: WO/2019/062848 International Application No.: PCT/CN2018/108316
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
C07D 221/20 (2006.01) ,C07D 211/38 (2006.01) ,C07D 205/04 (2006.01) ,A61K 31/397 (2006.01) ,A61K 31/438 (2006.01) ,A61K 31/445 (2006.01) ,A61P 25/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
221
Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/-C07D219/187
02
condensed with carbocyclic rings or ring systems
20
Spiro-condensed ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38
Halogen atoms or nitro radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
205
Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
397
having four-membered rings, e.g. azetidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
438
the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
04
Centrally acting analgesics, e.g. opioids
Applicants:
浙江海正药业股份有限公司 ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. [CN/CN]; 中国浙江省台州市 椒江区外沙路46号 No.46 Waisha Road Jiaojiang District Taizhou, Zhejiang 318000, CN
Inventors:
关东亮 GUAN, Dongliang; CN
王中利 WANG, Zhongli; CN
刘柱博 LIU, Zhubo; CN
孟力陈 MENG, Lichen; CN
赵伟峰 ZHAO, Weifeng; CN
凌龙 LING, Long; CN
王艳 WANG, Yan; CN
陈磊 CHEN, Lei; CN
Agent:
北京邦信阳专利商标代理有限公司 BOSS & YOUNG PATENT AND TRADEMARK LAW OFFICE; 中国北京市 朝阳区光华路7号汉威大厦东区25A3-1室 Room 25A3-1, East Wing, Hanwei Plaza No.7 Guanghua Road, Chaoyang District Beijing 100020, CN
Priority Data:
201710908313.029.09.2017CN
Title (EN) N-(SUBSTITUTED SULFONYL)BENZAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF
(FR) DÉRIVÉ DE N-(SULFONYLE SUBSTITUÉ)BENZAMIDE, PROCÉDÉ DE PRÉPARATION ET UTILISATION PHARMACEUTIQUE ASSOCIÉS
(ZH) N-(取代磺酰基)苯甲酰胺类衍生物及其制备方法和医药用途
Abstract:
(EN) The present invention discloses an N-(substituted sulfonyl)benzamide derivative, a preparation method therefor, and a pharmaceutical use thereof. Specifically, the present invention discloses an N-(substituted sulfonyl)benzamide derivative represented by a general formula (I), a preparation method therefor, and a pharmaceutically acceptable salt thereof, and their use as a therapeutic agent, particularly as Nav1.7 inhibitors. Definitions of the substituents in the general formula (I) are the same as those in the description.
(FR) L'invention concerne des dérivés N-(sulfonyle substituté)benzamide, un procédé de préparation et une utilisation pharmaceutique associés. L'invention concerne en particulier un dérivé de N-(sulfonyle substitué)benzamide représenté par une formule générale (I), un procédé de préparation et un sel pharmaceutiquement acceptable associés, ainsi que leur utilisation en tant qu'agent thérapeutique, en particulier en tant qu'inhibiteurs de Nav1.7. Les définitions de substituants dans la formule générale (I) sont identiques à celles de la description.
(ZH) 本发明公开了N-(取代磺酰基)苯甲酰胺类衍生物及其制备方法和医药用途。具体而言,本发明公开了一种通式(I)所示的N-(取代磺酰基)苯甲酰胺类衍生物、其制备方法及其可药用的盐,以及它们作为治疗剂,特别是作为Nav1.7抑制剂的用途,其中通式(I)中的各取代基的定义与说明书中的定义相同。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)