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1. (WO2019062844) FEMTOSECOND LASER MULTI-MODAL MOLECULAR IMAGING SYSTEM
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Pub. No.: WO/2019/062844 International Application No.: PCT/CN2018/108303
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
G01J 11/00 (2006.01) ,H01S 3/067 (2006.01)
G PHYSICS
01
MEASURING; TESTING
J
MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
11
Measuring the characteristics of individual optical pulses or of optical pulse trains
H ELECTRICITY
01
BASIC ELECTRIC ELEMENTS
S
DEVICES USING STIMULATED EMISSION
3
Lasers, i.e. devices for generation, amplification, modulation, demodulation, or frequency-changing, using stimulated emission, of infra-red, visible, or ultra-violet waves
05
Construction or shape of optical resonators; Accommodation of active medium therein; Shape of active medium
06
Construction or shape of active medium
063
Waveguide lasers, e.g. laser amplifiers
067
Fibre lasers
Applicants:
飞秒激光研究中心(广州)有限公司 FEMTOSECOND RESEARCH CENTER CO., LTD. [CN/CN]; 中国广东省广州市 高新技术产业开发区科学城揽月路80号科技创新基地A区616-618单元徐炳蔚 XU, Bingwei Unit 616-618, Zone A, Guangzhou High-Tech Innovation Center, No. 80 Lanyue Road, Huangpu District Guangzhou, Guangdong 510000, CN
Inventors:
徐炳蔚 XU, Bingwei; CN
朱欣 ZHU, Xin; CN
Agent:
北京市盈科律师事务所 BEIJING YINGKE LAW FIRM; 中国广东省广州市 天河区珠江新城冼村路5号凯华国际中心7-9楼江锦利 JIANG, Jinli 7-9/F, Central Tower, No.5 Xiancun Road, Zhujiang New Town, Tianhe District Guangzhou, Guangdong 510000, CN
Priority Data:
201710916860.330.09.2017CN
Title (EN) FEMTOSECOND LASER MULTI-MODAL MOLECULAR IMAGING SYSTEM
(FR) SYSTÈME D’IMAGERIE MOLÉCULAIRE MULTIMODALE À LASER FEMTOSECONDE
(ZH) 一种飞秒激光多模态分子影像系统
Abstract:
(EN) A femtosecond laser multi-modal molecular imaging system. A near-infrared waveband generation apparatus (1011) is used to provide a near-infrared waveband pulse, the central wavelength of same being 1010 nm to 1100 nm and the spectral width of same being less than 25 nm, wherein the near-infrared waveband pulse can excite an optical medium (1012) with a strong nonlinearity to generate a femtosecond laser pulse with an ultrawide optical spectrum, and a pulse measurement and compression control module (102) measures and compensates for chromatic dispersion accumulated by the femtosecond laser pulse reaching a tissue sample, so as to eliminate a time-domain widening effect to the maximum possible extent, and an obtained shortest pulse can act with the tissue sample to generate various optical spectrum signals of different modalities, so as to provide various nonlinear molecular imaging modalities.
(FR) La présente invention concerne un système d’imagerie moléculaire multimodale à laser femtoseconde. Un appareil de génération de bande d’onde infrarouge proche (1011) est utilisé pour fournir une impulsion de bande d’onde infrarouge proche, la longueur d’onde centrale de celle-ci étant de 1010 nm à 1100 nm et la largeur spectrale de celle-ci étant inférieure à 25 nm, l’impulsion de bande d’onde infrarouge proche pouvant exciter un support optique (1012) avec une non linéarité forte pour générer une impulsion laser femtoseconde avec un spectre optique ultralarge, et un module de commande de mesure et de compression d’impulsion (102) mesure et compense la dispersion chromatique accumulée par l’impulsion laser femtoseconde atteignant un échantillon de tissu, de façon à éliminer un effet d’élargissement de domaine temporel au plus haut degré possible, et une impulsion la plus courte obtenue peut agir avec l’échantillon de tissu pour générer différents signaux de spectre optique de différentes modalités, de façon à produire différentes modalités d’imagerie moléculaire non linéaire.
(ZH) 一种飞秒激光多模态分子影像系统,采用近红外波段生成装置(1011)提供中心波长为1010纳米至1100纳米、谱宽小于25纳米的近红外波段脉冲,近红外波段脉冲可激发具有强非线性的光学媒介(1012)产生具有超宽光谱的飞秒激光脉冲,通过脉冲测量压缩控制模块(102)测量并补偿飞秒激光脉冲到达组织样品积累的色散,最大限度消除时域展宽效应,得到的最短脉冲可以与组织样品作用生成多种不同模态的光谱信号,从而提供多种非线性分子影像模态。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)