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1. (WO2019062831) IL-5 ANTIBODY, ANTIGEN BINDING FRAGMENT THEREOF, AND MEDICAL APPLICATION THEREFOR
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Pub. No.: WO/2019/062831 International Application No.: PCT/CN2018/108240
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
C07K 16/24 (2006.01) ,C07K 16/18 (2006.01) ,A61K 39/395 (2006.01) ,C12N 15/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
02
Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
Applicants:
江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN/CN]; 中国江苏省连云港市 经济技术开发区昆仑山路7号 No.7 Kunlunshan Road, Economic and Technological Development Zone Lianyungang, Jiangsu 222047, CN
上海恒瑞医药有限公司 SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. [CN/CN]; 中国上海市 闵行区文井路279号 No.279 Wenjing Road, Minhang District Shanghai 200245, CN
Inventors:
应华 YING, Hua; CN
石金平 SHI, Jinping; CN
王义芳 WANG, Yifang; CN
胡齐悦 HU, Qiyue; CN
葛虎 GE, Hu; CN
陶维康 TAO, Weikang; CN
Agent:
北京戈程知识产权代理有限公司 GE CHENG & CO., LTD.; 中国北京市 东城区东长安街1号东方广场东三办公楼19层程伟 CHENG, David W. Level 19, Tower E3, the Towers, Oriental Plaza, No.1, East Chang An Avenue, Dongcheng District Beijing 100738, CN
Priority Data:
201710906068.X29.09.2017CN
Title (EN) IL-5 ANTIBODY, ANTIGEN BINDING FRAGMENT THEREOF, AND MEDICAL APPLICATION THEREFOR
(FR) ANTICORPS IL-5, SON FRAGMENT LIANT L'ANTIGÈNE ET SON UTILISATION MÉDICALE
(ZH) IL-5抗体、其抗原结合片段及医药用途
Abstract:
(EN) Provided are an IL-5 antibody, an antigen binding fragment thereof, and a medical application therefor. The present invention comprises a mouse-derived antibody containing an IL-5 antibody CDR region, a chimeric antibody, a humanized antibody, and a pharmaceutical composition comprising said IL-5 antibody and said antigen binding fragment thereof, as well as the use of the pharmaceutical composition as a drug.
(FR) L'invention concerne un anticorps IL-5, son fragment liant l'antigène et son utilisation médicale. Elle comprend un anticorps dérivé d'une souris contenant une région CDR anticorps IL-5, un anticorps chimérique, un anticorps humanisé, une composition pharmaceutique comprenant ledit anticorps IL-5 et son fragment liant l'antigène, ainsi que l'utilisation de ladite composition pharmaceutique comme médicament.
(ZH) IL-5抗体、其抗原结合片段及医药用途。包含IL-5抗体CDR区的鼠源抗体、嵌合抗体、人源化抗体,以及包含IL-5抗体及其抗原结合片段的药物组合物,以及其作为药物的用途。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)