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1. (WO2019062817) ENGINEERED IMMUNE CELL CAPABLE OF INDUCING SECRETION OF ANTI-CD47 ANTIBODY
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Pub. No.: WO/2019/062817 International Application No.: PCT/CN2018/108022
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
C12N 5/10 (2006.01) ,A61K 35/17 (2015.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
亘喜生物科技(上海)有限公司 GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD. [CN/CN]; 中国上海市 徐汇区宜山路926号1幢12层 12th Floor, Building 1, 926 Yishan Road Xuhui District Shanghai 200233, CN
Inventors:
张永亮 ZHANG, Yongliang; CN
刘丽萍 LIU, Liping; CN
曹卫 CAO, Wei; CN
马琳 MA, Lin; CN
马安云 MA, Anyun; CN
何佳平 HE, Jiaping; CN
沈连军 SHEN, Lianjun; CN
Agent:
上海一平知识产权代理有限公司 XU & PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room 106, Building No. 1, Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201710891841.X27.09.2017CN
Title (EN) ENGINEERED IMMUNE CELL CAPABLE OF INDUCING SECRETION OF ANTI-CD47 ANTIBODY
(FR) CELLULE IMMUNITAIRE MODIFIÉE CAPABLE D'INDUIRE LA SÉCRÉTION D'ANTICORPS ANTI-CD47
(ZH) 可诱导分泌抗CD47抗体的工程化免疫细胞
Abstract:
(EN) Provided are an immune cell capable of inducing the secretion of an anti-CD47 antibody when a CAR and/or an exogenous TCR is activated, a use thereof, and a preparation comprising the immune cell. Also provided are a preparation method of the immune cell and a kit for the preparation method.
(FR) L'invention concerne une cellule immunitaire capable d'induire la sécrétion d'un anticorps anti-CD47 lorsqu'un CAR et/ou un TCR exogène est activé, une utilisation de celle-ci, et une préparation comprenant la cellule immunitaire. L'invention concerne également un procédé de préparation de la cellule immunitaire et un kit pour le procédé de préparation.
(ZH) 提供了一种在CAR和/或外源TCR被激活时可诱导分泌抗CD47抗体的免疫细胞及其用途、含有所述免疫细胞的制剂,还提供了所述免疫细胞的制备方法以及用于所述制备方法的试剂盒。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)