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1. (WO2019062661) NEURAMINIDASE INHIBITORS CONTAINING CARBAMIDO, AND MEDICAL USES THEREOF
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Pub. No.: WO/2019/062661 International Application No.: PCT/CN2018/106952
Publication Date: 04.04.2019 International Filing Date: 21.09.2018
IPC:
C07C 279/16 (2006.01) ,C07C 279/24 (2006.01) ,A61K 31/196 (2006.01) ,A61K 31/215 (2006.01) ,A61K 31/27 (2006.01) ,A61P 31/12 (2006.01) ,A61P 31/16 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
279
Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
16
having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
279
Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
20
containing any of the groups X being a hetero atom, Y being any atom, e.g. acylguanidines
24
Y being a hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
196
the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
27
of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
16
for influenza or rhinoviruses
Applicants:
沈阳药科大学 SHENYANG PHARMACEUTICAL UNIVERSITY [CN/CN]; 中国辽宁省沈阳市 沈河区文化路103号 103 Wenhua Road, Shenhe District Shenyang, Liaoning 110016, CN
Inventors:
田永寿 TIAN, Yongshou; CN
王矿磊 WANG, Kuanglei; CN
Agent:
沈阳杰克知识产权代理有限公司 SHENYANG JACK INTELLECTUAL PROPERTY AGENT LTD.; 中国辽宁省沈阳市 皇姑区长江街136号1-4-13靳玲 JIN, Ling 1-4-13, No. 136, Changjiang Street, Huanggu District Shenyang, Liaoning 110031, CN
Priority Data:
201710881483.426.09.2017CN
Title (EN) NEURAMINIDASE INHIBITORS CONTAINING CARBAMIDO, AND MEDICAL USES THEREOF
(FR) INHIBITEURS DE NEURAMINIDASE CONTENANT DES CARBAMIDO, ET LEURS UTILISATIONS MÉDICALES
(ZH) 含脲基的神经氨酸酶抑制剂及其医药用途
Abstract:
(EN) The present invention relates to the field of pharmaceutical chemistry, and specifically, to a kind of oseltamivir derivatives that are neuraminidase inhibitors containing carbamido, a preparation method therefor, and medical uses thereof. The derivatives are mainly used for treating infectious diseases caused by viruses. The compounds in the present invention are derivatives represented by formula (I), and pharmaceutically-acceptable salts or isomers, R1, R2 and R3 being described in the claims and the specification.
(FR) La présente invention se rapporte au domaine de la chimie pharmaceutique, et concerne particulièrement un type de dérivés d'oseltamivir qui sont des inhibiteurs de neuraminidase contenant des carbamido, leur procédé de préparation, et leurs utilisations médicales. Les dérivés sont principalement utilisés pour traiter des maladies infectieuses provoquées par des virus. Les composés selon la présente invention sont des dérivés représentés par la formule (I), et des sels ou isomères pharmaceutiquement acceptables, R1, R2 et R3 étant décrits dans les revendications et la spécification.
(ZH) 本发明涉及药物化学领域,具体是一类含脲基的神经氨酸酶抑制剂奥司他韦衍生物、其制备方法及其医药用途,医药用途主要用于治疗由病毒引起的感染性疾病。本发明的化合物为具有如下通式(I)所示的衍生物及其药学上可接受的盐或异构体,其中,R1、R2、R3如权利要求书和说明书所述。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)