Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019062657) NITROGEN HETEROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/062657 International Application No.: PCT/CN2018/106885
Publication Date: 04.04.2019 International Filing Date: 21.09.2018
IPC:
C07D 401/06 (2006.01) ,C07D 403/06 (2006.01) ,C07D 471/04 (2006.01) ,A61K 31/4184 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4184
condensed with carbocyclic rings, e.g. benzimidazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
北京越之康泰生物医药科技有限公司 BEIJING YUEZHIKANGTAI BIOMEDICINES CO., LTD. [CN/CN]; 中国北京市 昌平区回龙观镇生命园路29号1幢3层 Level 3, Bldg.1 No.29 Shengmingyuan Rd., Huilongguan Town, Changping District Beijing 102200, CN
Inventors:
段茂圣 DUAN, Maosheng; CN
熊艳林 XIONG, Yanlin; CN
刘佳乐 LIU, Jiale; CN
田世鸿 TIAN, Shihong; CN
戴权 DAI, Quan; CN
Agent:
北京戈程知识产权代理有限公司 GE CHENG & CO., LTD.; 中国北京市 东城区东长安街1号东方广场东三办公楼19层1901(DavidW.Cheng) David W. Cheng Level 19, Tower E3, the Towers, Oriental Plaza No.1 East Chang An Avenue, Dongcheng District Beijing 100738, CN
Priority Data:
201710914512.230.09.2017CN
Title (EN) NITROGEN HETEROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF
(FR) DÉRIVÉ HÉTÉROCYLIQUE D'AZOTE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION PHARMACEUTIQUE
(ZH) 氮杂环类衍生物、其制备方法及其医药用途
Abstract:
(EN) The present invention relates to a nitrogen heterocyclic derivative, a preparation method therefor, and a pharmaceutical use thereof. In particular, the present invention relates to a nitrogen heterocyclic derivative represented by the general formula (I), a preparation method therefor, a pharmaceutical composition containing the same, and a use thereof as an SMO antagonist, particularly in the treatment of Hedgehog signaling pathway-associated diseases such as cancer. The definitions of the groups in the general formula (I) are the same as those in the specification.
(FR) La présente invention concerne dun dérivé hétérocyclique d'azote, une méthode de préparation de ce dernier, et une utilisation pharmaceutique de ce dernier. En particulier, l'invention concerne un dérivé hétérocyclique d'azote représenté par la formule générale (I), son procédé de préparation, une composition pharmaceutique le contenant, et son utilisation en tant qu'antagoniste de SMO, en particulier pour traiter des maladies associées à la voie de signalisation Hedgehog telles que le cancer. Les définitions des groupes dans la formule générale (I) sont les mêmes que celles données dans la description.
(ZH) 本发明涉及一种氮杂环类衍生物、其制备方法及其医药用途。特别地,本发明涉及通式(I)所示的氮杂环类衍生物、其制备方法、含有该衍生物的药物组合物,以及其作为SMO拮抗剂,特别是在治疗与Hedgehog信号通路相关的疾病如癌症中的用途。其中通式(I)中的各基团的定义与说明书中的定义相同。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)