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1. (WO2019062642) DOUBLE TARGETING FUSION PROTEIN TARGETING PD-1 OR PD-L1 AND TARGETING VEGF FAMILY AND USE THEREOF
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Pub. No.: WO/2019/062642 International Application No.: PCT/CN2018/106741
Publication Date: 04.04.2019 International Filing Date: 20.09.2018
IPC:
C07K 19/00 (2006.01) ,C12N 15/62 (2006.01) ,C12N 15/63 (2006.01) ,G01N 33/68 (2006.01) ,G01N 33/574 (2006.01) ,A61K 39/395 (2006.01) ,A61K 38/18 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
北京比洋生物技术有限公司 BEIJING BEYOND BIOTECHNOLOGY CO., LTD [CN/CN]; 中国北京市 大兴区亦庄经济技术开发区西环南路18号汇龙森C座308室 Room 308, C Building, No. 18 Xihuannanlu Street, BDA Beijing 100176, CN
Inventors:
胡品良 HU, Pinliang; CN
邹敬 ZOU, Jing; CN
洪伟东 HONG, Weidong; CN
何芸 HE, Yun; CN
白洁 BAI, Jie; CN
宋凌云 SONG, Lingyun; CN
杨文第 YANG, Wendi; CN
Agent:
北京市中咨律师事务所 ZHONGZI LAW OFFICE; 中国北京市 西城区平安里西大街26号新时代大厦7层 7F, New Era Building, 26 Pinganli Xidajie, Xicheng District Beijing 100034, CN
Priority Data:
201710905683.929.09.2017CN
Title (EN) DOUBLE TARGETING FUSION PROTEIN TARGETING PD-1 OR PD-L1 AND TARGETING VEGF FAMILY AND USE THEREOF
(FR) PROTÉINE DE FUSION À DOUBLE CIBLAGE CIBLANT PD-1 OU PD-L1 ET CIBLANT LA FAMILLE DU VEGF ET SON UTILISATION
(ZH) 靶向PD-1或PD-L1且靶向VEGF家族的双靶向融合蛋白及其用途
Abstract:
(EN) A double targeting fusion protein targeting PD-1 or PD-L1 and targeting VEGF family. Said double targeting fusion protein comprises (i) an anti-PD-1 antibody or an anti-PD-L1 antibody, and (ii) a VID effectively linked at the C-terminus of each of two heavy chains of said anti-PD-1 antibody or anti-PD-L1 antibody. Provided are a polynucleotide encoding the double targeting fusion protein, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, and use of the double targeting fusion protein in the treatment, prevention and/or diagnosis of diseases associated with PD-1 activity, PD-L1 activity and VEGF family activity in an individual.
(FR) L'invention concerne une protéine de fusion à double ciblage ciblant PD-1 ou PD-L1 et ciblant la famille du VEGF. Ladite protéine de fusion à double ciblage comprend (i) un anticorps anti-PD-1 ou un anticorps anti-PD-L1, et (ii) un VID lié de manière fonctionnelle à l'extrémité C-terminale de chacune de deux chaînes lourdes dudit anticorps anti-PD-1 ou dudit anticorps anti-PD-L1. L'invention concerne un polynucléotide codant pour la protéine de fusion à double ciblage, un vecteur comprenant le polynucléotide, une cellule hôte comprenant le polynucléotide ou le vecteur, et l'utilisation de la protéine de fusion à double ciblage dans le traitement, la prévention et/ou le diagnostic de maladies associées à l'activité PD-1, à l'activité PD-L1 et à l'activité de la famille du VEGF chez un individu.
(ZH) 一种靶向PD-1或PD-L1且靶向VEGF家族这两者的双靶向融合蛋白,所述双靶向融合蛋白包含(i)抗PD-1抗体或者抗PD-L1抗体和(ii)在所述抗PD-1抗体或者抗PD-L1抗体的两条重链中的每一重链的C端有效连接的一个VID。提供了编码所述双靶向融合蛋白的多核苷酸、包含所述多核苷酸的载体、包含所述多核苷酸或载体的宿主细胞、以及所述双靶向融合蛋白在个体中治疗、预防和/或诊断与PD-1活性、PD-L1活性和VEGF家族活性相关的疾病中的用途。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)