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1. (WO2019062637) QUINOLINE DERIVATIVE AND APPLICATION THEREOF AS TYROSINE KINASE INHIBITOR
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Pub. No.: WO/2019/062637 International Application No.: PCT/CN2018/106674
Publication Date: 04.04.2019 International Filing Date: 20.09.2018
IPC:
A61K 31/47 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
南京明德新药研发股份有限公司 MEDSHINE DISCOVERY INC. [CN/CN]; 中国江苏省南京市 南京高新开发区高新路9号商务办公楼218室 Room 218, No.9 Gaoxin Road, Gaoxin Development District Nanjing, Jiangsu 210032, CN
Inventors:
张杨 ZHANG, Yang; CN
陈正霞 CHEN, Zhengxia; CN
戴美碧 DAI, Meibi; CN
李文举 LI, Wenju; CN
黎健 LI, Jian; CN
陈曙辉 CHEN, Shuhui; CN
Agent:
上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE; 中国上海市 小木桥路681号外经大厦21楼 21st Floor SFECO Mansion 681 Xiaomuqiao Road Shanghai 200032, CN
Priority Data:
201710900497.628.09.2017CN
201810732319.105.07.2018CN
Title (EN) QUINOLINE DERIVATIVE AND APPLICATION THEREOF AS TYROSINE KINASE INHIBITOR
(FR) DÉRIVÉ DE QUINOLINE ET SON APPLICATION EN TANT QU'INHIBITEUR DE TYROSINE KINASE
(ZH) 喹啉衍生物及其作为酪氨酸激酶抑制剂的应用
Abstract:
(EN) A quinoline derivative compound shown in formula (II), a pharmaceutically acceptable salt thereof, and an application of the same in preparing a drug for treating a disease related to a tyrosine kinase inhibitor.
(FR) L'invention concerne un composé dérivé de quinoline représenté par la formule (II), un sel pharmaceutiquement acceptable de celui-ci, et une application dudit composé dans la préparation d'un médicament pour le traitement d'une maladie liée à un inhibiteur de tyrosine kinase.
(ZH) 式(II)所示的喹啉衍生物化合物及其药学上可接受的盐以及它们在制备治疗与酪氨酸激酶抑制剂相关疾病的药物中的应用。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)