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1. (WO2019062234) ISOLATED RECOMBINANT ONCOLYTIC POXVIRUS, PHARMACEUTICAL COMPOSITION, AND USE THEREOF IN TREATMENT OF TUMORS AND/OR CANCER
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Pub. No.: WO/2019/062234 International Application No.: PCT/CN2018/093404
Publication Date: 04.04.2019 International Filing Date: 28.06.2018
IPC:
C12N 7/01 (2006.01) ,C12N 15/09 (2006.01) ,A61K 35/768 (2015.01) ,A61K 39/285 (2006.01) ,A61K 48/00 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01
Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
[IPC code unknown for A61K 35/768]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
275
Poxviridae, e.g. avipoxvirus
285
Vaccinia virus or variola virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
杭州康万达医药科技有限公司 HANGZHOU CONVERD CO., LTD. [CN/CN]; 中国浙江省杭州市 余杭区仓前街道余杭塘路2959号4幢7层 7th Floor, Building #4, 2959 Yuhangtang Road, Yuhang District Hangzhou, Zhejiang 311121, CN
Inventors:
傅瑾 FU, Jin; CN
赵荣华 ZHAO, Ronghua; CN
张蓉 ZHANG, Rong; CN
王婷婷 WANG, Tingting; CN
陈霖 CHEN, Lin; CN
胡放 HU, Fang; CN
Agent:
北京天昊联合知识产权代理有限公司 TEE & HOWE INTELLECTUAL PROPERTY ATTORNEYS; 中国北京市 东城区建国门内大街28号民生金融中心D座10层丁业平 DING Yeping 10th Floor, Tower D, Minsheng Financial Center, 28 Jianguomennei Avenue, Dongcheng District Beijing 100005, CN
Priority Data:
201710882027.126.09.2017CN
Title (EN) ISOLATED RECOMBINANT ONCOLYTIC POXVIRUS, PHARMACEUTICAL COMPOSITION, AND USE THEREOF IN TREATMENT OF TUMORS AND/OR CANCER
(FR) POXVIRUS ONCOLYTIQUE RECOMBINÉ ISOLÉ, COMPOSITION PHARMACEUTIQUE, ET UTILISATION ASSOCIÉE DANS LE TRAITEMENT DE TUMEURS ET/OU DU CANCER
(ZH) 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
Abstract:
(EN) An isolated recombinant oncolytic poxvirus, a pharmaceutical composition, and a use thereof in the treatment of tumors and/or cancer. The isolated recombinant oncolytic poxvirus is functionally deficient in the TK gene and the VGF gene, and an exogenous IL-21 gene is integrated into the genome of the recombinant oncolytic poxvirus. The IL-21 gene can be expressed in tumor cells.
(FR) L'invention concerne un poxvirus oncolytique recombiné isolé, une composition pharmaceutique, et une utilisation associée dans le traitement de tumeurs et/ou du cancer. Le poxvirus oncolytique recombiné isolé est fonctionnellement déficient en gène TK et en gène VGF, et un gène IL-21 exogène est intégré dans le génome du poxvirus oncolytique recombiné. Le gène IL-21 peut être exprimé dans les cellules tumorales.
(ZH) 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途。该分离的重组溶瘤痘病毒是TK基因和VGF基因功能缺陷型的,并且该重组溶瘤痘病毒的基因组中整合有外源IL-21基因,该IL-21基因能够在肿瘤细胞中表达。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)