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1. (WO2019061562) NUCLEIC ACID MOLECULE WHICH ENHANCES ANTITUMOR ACTIVITY OF T CELLS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/061562 International Application No.: PCT/CN2017/106080
Publication Date: 04.04.2019 International Filing Date: 13.10.2017
IPC:
C07K 19/00 (2006.01) ,C12N 5/10 (2006.01) ,C12N 15/62 (2006.01) ,C12N 15/867 (2006.01) ,A61K 35/17 (2015.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
深圳市体内生物医药科技有限公司 SHENZHEN IN VIVO BIOMEDICINE TECHNOLOGY LIMITED COMPANY [CN/CN]; 中国广东省深圳市 宝安区西乡街道固戍社区红湾工业区五栋5楼 5/F Building NO.5, Red Bay Industrial Zone, Gushu Community, Xixiang Street, Bao'An District Shenzhen, Guangdong 518100, CN
Inventors:
李鹏 LI, Peng; CN
赵若聪 ZHAO, Ruocong; CN
蒋治武 JIANG, Zhiwu; CN
秦乐 QIN, Le; CN
林思妙 LIN, Simiao; CN
姚瑶 YAO, Yao; CN
Agent:
北京品源专利代理有限公司 BEYOND ATTORNEYS AT LAW; 中国北京市 海淀区莲花池东路39号西金大厦6层 F6, Xijin Centre 39 Lianhuachi East Rd., Haidian District Beijing 100036, CN
Priority Data:
201710920012.X30.09.2017CN
Title (EN) NUCLEIC ACID MOLECULE WHICH ENHANCES ANTITUMOR ACTIVITY OF T CELLS
(FR) MOLÉCULE D'ACIDE NUCLÉIQUE PERMETTANT D'AMÉLIORER L'ACTIVITÉ ANTITUMORALE DE LYMPHOCYTES T
(ZH) 一种增强T细胞抗肿瘤活性的核酸分子
Abstract:
(EN) Provided is a new chimeric antigen receptor (CAR) molecule containing a DAP10 protein intracellular segment, and a nucleic acid for encoding same, a cell expressing same, and a use thereof in the preparation of a drug for treating tumors. The CAR molecule is achieved by introducing an intracellular segment of DAP10 protein into a conventional second-generation CAR molecule, which activates the T cell DAP10 downstream signaling pathway by means of binding the CAR molecule to a target antigen, so as to enhance the killing effect of the corresponding CART cells on solid tumors in vivo and in vitro, thereby enhancing the ability of the molecule to proliferate and survive.
(FR) L'invention concerne une nouvelle molécule du récepteur antigénique chimèrique (CAR) contenant un segment intracellulaire protéique DAP10, et un acide nucléique codant pour celle-ci, une cellule exprimant celle-ci, et une utilisation de ladite molécule dans la préparation d'un médicament pour le traitement de tumeurs. La molécule CAR est obtenue par introduction d'un segment intracellulaire protéique DAP10 dans une molécule CAR classique de deuxième génération, activant la voie de signalisation en aval du DAP10 de lymphocyte T au moyen de la liaison de la molécule CAR à un antigène cible, de manière à améliorer l'effet destructeur des cellules CART correspondantes sur des tumeurs solides in vivo et in vitro, ce qui permet d'améliorer la capacité de la molécule à proliférer et à survivre.
(ZH) 提供了一种含DAP10蛋白胞内段的新的嵌合抗原受体(CAR)分子,以及编码其的核酸,表达其的细胞,以及其在制备治疗肿瘤的药物中的用途。所述CAR分子是在传统的第二代CAR分子中引入DAP10蛋白的胞内段而实现的,其通过CAR分子与靶抗原结合后激活T细胞DAP10下游信号通路,以提升相应的CART细胞对实体肿瘤在体内、体外的杀伤作用,增强其增殖存活能力。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)