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1. (WO2019060994) COMPOUNDS FOR USE IN THE TREATMENT OR PREVENTION OF LOWE SYNDROME OR DENT DISEASE, AND METHODS THEREFOR
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Pub. No.: WO/2019/060994 International Application No.: PCT/CA2018/051218
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
A61K 31/18 (2006.01) ,A61P 13/12 (2006.01) ,A61P 3/00 (2006.01) ,C07C 311/21 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
18
Sulfonamides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15
Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
21
having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Applicants:
UNIVERSITÉ DE MONTRÉAL [CA/CA]; 2900 Boulevard Edouard Montpetit Montréal, Québec H3T 1J4, CA
THE UNIVERSITY OF MANCHESTER [GB/GB]; Oxford Road Manchester Greater Manchester M13 9PL, GB
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR/FR]; 3 rue Michel-Ange 75794 Paris Cedex 16, FR
SORBONNE UNIVERSITÉ [FR/FR]; 21 rue de l'École de Médecine 75006 Paris, FR
INSTITUT PASTEUR [FR/FR]; 25-28 rue du Docteur Roux 75724 Paris Cedex 15, FR
Inventors:
CARRENO, Sébastien; CA
BEN EL KADHI, Khaled; CA
ECHARD, Arnaud; FR
CAUVIN, Clothilde; FR
LOWE, Martin; GB
Agent:
ROBIC LLP; 1001 Square-Victoria, Bloc E, 8th floor Montréal, Québec H2Z 2B7, CA
Priority Data:
2.980.43127.09.2017CA
Title (EN) COMPOUNDS FOR USE IN THE TREATMENT OR PREVENTION OF LOWE SYNDROME OR DENT DISEASE, AND METHODS THEREFOR
(FR) COMPOSÉS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT OU LA PRÉVENTION DU SYNDROME DE LOWE OU DE LA MALADIE DE DENT, ET MÉTHODES CORRESPONDANTES
Abstract:
(EN) Compounds, compositions and their use in the treatment or prevention of symptoms of Lowe Syndrome and Dent disease 2 are described, for instance, the use of such compounds in the treatment of Lowe Syndrome and Dent disease 2, or in the treatment or prevention of at least one symptom associated therewith. The compounds disclosed are of Formula I:
(FR) L'invention concerne des composés, des compositions et leur utilisation dans le traitement ou la prévention de symptômes du syndrome de Lowe et de la maladie de Dent de type 2, par exemple l'utilisation de tels composés dans le traitement du syndrome de Lowe et de la maladie de Dent de type 2, ou dans le traitement ou la prévention d'au moins un symptôme associé. Les composés de l'invention correspondent à la formule I :
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)