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1. WO2019059476 - PEPTIDE FOR INHIBITING ANGIOGENESIS AND USE THEREOF

Publication Number WO/2019/059476
Publication Date 28.03.2019
International Application No. PCT/KR2018/002978
International Filing Date 14.03.2018
IPC
C07K 7/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
A23L 33/18 2016.1
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
17Amino acids, peptides or proteins
18Peptides; Protein hydrolysates
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A23L 33/18
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
17Amino acids, peptides or proteins
18Peptides; Protein hydrolysates
A23V 2002/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2002Food compositions, function of food ingredients or processes for food or foodstuffs
A23V 2200/30
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2200Function of food ingredients
30Foods, ingredients or supplements having a functional effect on health
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/71
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
Applicants
  • (주)케어젠 CAREGEN CO., LTD. [KR]/[KR]
Inventors
  • 정용지 CHUNG, Yong Ji
  • 김은미 KIM, Eun Mi
  • 이응지 LEE, Eung Ji
Agents
  • 특허법인 태평양 BAE, KIM & LEE IP GROUP
Priority Data
10-2017-012257122.09.2017KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) PEPTIDE FOR INHIBITING ANGIOGENESIS AND USE THEREOF
(FR) PEPTIDE UTILISÉ POUR INHIBER L'ANGIOGENÈSE ET SON UTILISATION
(KO) 혈관신생 억제용 펩타이드 및 이의 용도
Abstract
(EN) The present invention relates to a novel peptide having an angiogenesis inhibitory activity and a use of the peptide, related to the treatment or prevention of excessive angiogenesis-related diseases. Particularly, a novel peptide according to the present invention binds, in competition with vascular endothelial growth factors (VEGF), to VEGF receptors and can significantly inhibit the proliferation, migration and differentiation of vascular endothelial cells, thereby being effectively usable as an active ingredient of a composition or a health functional food for preventing or treating diseases, such as macular degeneration, a tumor, arthritis or psoriasis, caused by excessive angiogenesis.
(FR) L'invention concerne un nouveau peptide présentant une activité inhibitrice de l'angiogenèse; et une utilisation du peptide en relation avec le traitement ou la prévention de maladies liées à l'angiogenèse excessive. En particulier, un nouveau peptide de l'invention se lie, en concurrence avec des facteurs de croissance de l'endothélium vasculaire (VEGF), à des récepteurs de VEGF et peut inhiber considérablement la prolifération, la migration et la différenciation de cellules de l'endothélium vasculaire, et peut donc s'utiliser efficacement comme principe actif d'une composition ou d'un aliment fonctionnel pour la santé pour prévenir ou traiter des maladies, telles que la dégénérescence maculaire, une tumeur, l'arthrite ou le psoriasis, dues à une angiogenèse excessive.
(KO) 본 발명은 혈관신생(angiogenesis) 억제 활성을 갖는 신규 펩타이드 및 신생혈관의 과잉 형성과 관련된 질환의 치료 또는 예방과 관련된 상기 펩타이드의 용도에 관한 것이다. 구체적으로 본 발명에 따른 신규 펩타이드는 VEGF(vascular endothelial growth factor)의 수용체에 대해 VEGF와 경쟁적으로 결합하고, 혈관내피세포의 증식, 이동 및 분화를 현저하게 억제할 수 있다. 따라서, 과도한 신생혈관 형성으로 인한 황반변성(macular degeneration), 종양(t㎛or), 관절염(arthritis) 또는 건선(psoriasis) 등과 같은 질환을 예방 또는 치료하는 조성물이나 건강기능식품의 유효성분으로 유용하게 사용될 수 있는 장점이 있다.
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