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1. WO2019057222 - SLUG EXTRACT, METHOD FOR EXTRACTING AND SEPARATING EFFECTIVE COMPONENT IN EXTRACT, AND USE

Publication Number WO/2019/057222
Publication Date 28.03.2019
International Application No. PCT/CN2018/115651
International Filing Date 15.11.2018
IPC
A61K 35/618 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
56Materials from animals other than mammals
618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
A61P 25/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
36Opioid-abuse
C07J 9/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
9Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
A61K 31/575 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A23L 33/00 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
CPC
A23L 33/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
A23L 33/10
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A23V 2002/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2002Food compositions, function of food ingredients or processes for food or foodstuffs
A23V 2200/334
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2200Function of food ingredients
30Foods, ingredients or supplements having a functional effect on health
334treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
A61K 2236/37
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Applicants
  • 广西久福生物科技有限公司 GUANGXI JIUFU BIOTECHNOLOGY CO., LTD [CN]/[CN]
Inventors
  • 阮俊 RUAN, Jun
Agents
  • 深圳新创友知识产权代理有限公司 CHINA TRUER IP
Priority Data
201710868174.322.09.2017CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) SLUG EXTRACT, METHOD FOR EXTRACTING AND SEPARATING EFFECTIVE COMPONENT IN EXTRACT, AND USE
(FR) EXTRAIT DE LIMACE, PROCÉDÉ D'EXTRACTION ET DE SÉPARATION D'UN COMPOSANT EFFICACE DANS UN EXTRAIT, ET UTILISATION
(ZH) 蛞蝓提取物、提取物中有效成分提取分离方法及用途
Abstract
(EN)
A slug extract and an effective component therein, the extract being obtained by performing supercritical CO2 extraction or organic solvent reflux extraction, saponification, extraction with an organic solvent and organic solvent recovery, the effective component being obtained by further performing extraction and separation on the extract. The extract has sedating and sleep-inducing effects, has an inhibiting effect with regard to excitability in mice caused by morphine and amphetamine, and has a drug detoxification treatment effect with regard to withdrawal symptoms in morphine-dependent rats.
(FR)
L'invention concerne un extrait de limace, obtenu à partir d'une limace en effectuant une extraction au CO2 supercritique ou une extraction par reflux de solvant organique, la réalisation d'une saponification pour obtenir une solution de réaction, la réalisation d'une extraction sur la solution de réaction avec un solvant organique, et la récupération du solvant organique à partir d'une solution d'extraction. Une étude pharmacologique montre que l'extrait a des effets sédatifs et hypnotiques, a un effet inhibiteur vis-à-vis de l'excitabilité chez des souris provoquée par la morphine et l'amphétamine, et a un effet de désintoxication vis-à-vis des symptômes de sevrage chez des rats dépendants à la morphine sans dépendance physique ou mentale. L'extrait a une bonne valeur sur le plan social et sur le plan économique, et joue un rôle important dans le développement de médicaments efficaces et sûrs pour le traitement de la toxicomanie. L'invention concerne également un procédé d'extraction et de séparation d'un composant efficace dans l'extrait de limace.
(ZH)
一种蛞蝓提取物及其中的有效成分,该提取物经超临界CO2萃取或以有机溶媒回流提取、皂化后,采用有机溶剂萃取、回收有机溶剂制备而得;有效成分为提取物进一步提取分离获得。该提取物具有镇静催眠作用,对吗啡和苯丙胺引起的小鼠兴奋性具有抑制作用,对吗啡依赖大鼠戒断症状具有脱毒治疗效果。
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Latest bibliographic data on file with the International Bureau