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1. WO2019055930 - METHODS FOR IDENTIFYING MYELOMA TUMOR-INITIATING CELLS AND TARGETED THERAPY

Publication Number WO/2019/055930
Publication Date 21.03.2019
International Application No. PCT/US2018/051363
International Filing Date 17.09.2018
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/70596
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70596Molecules with a "CD"-designation not provided for elsewhere
C07K 16/2896
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2896against molecules with a "CD"-designation, not provided for elsewhere
G01N 2333/70596
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
705Assays involving receptors, cell surface antigens or cell surface determinants
70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
Applicants
  • UNIVERSITY OF IOWA RESEARCH FOUNDATION [US]/[US]
Inventors
  • FRECH, Ivana
  • ZHAN, Fenghuang
  • TRICOT, Guido
Agents
  • VIKSNINS, Ann S.
  • HARRIS, Robert
  • MALEN, Peter L.
  • KRUGER, Katherine A.D.
  • ANDRUS, Alex
  • MICKELSON, John W.
  • PADYS, Dan J.
Priority Data
62/559,27215.09.2017US
62/593,71701.12.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR IDENTIFYING MYELOMA TUMOR-INITIATING CELLS AND TARGETED THERAPY
(FR) PROCÉDÉS D'IDENTIFICATION DE CELLULES INITIATRICES DE TUMEUR DE MYÉLOME ET THÉRAPIE CIBLÉE
Abstract
(EN)
In certain embodiments, the present invention provides a method of treating cancer in a patient comprising administering an effective amount of a therapeutic agent to the patient, wherein the cancer was determined to contain cells comprising cell marker CD24+. In certain embodiments, the cancer cells also comprise cell markers CD38+ and/or CD45-.
(FR)
Dans certains modes de réalisation, la présente invention concerne une méthode de traitement du cancer chez un patient comportant l'étape consistant à administrer une quantité efficace d'un agent thérapeutique au patient, le cancer ayant été déterminé comme contenant des cellules comprenant le marqueur cellulaire CD24+. Dans certains modes de réalisation, les cellules cancéreuses comprennent également les marqueurs cellulaires CD38+ et/ou CD45-.
Also published as
Latest bibliographic data on file with the International Bureau