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1. (WO2019055689) HEAVY CHAIN ANTIBODIES BINDING TO ECTOENZYMES
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/055689 International Application No.: PCT/US2018/050931
Publication Date: 21.03.2019 International Filing Date: 13.09.2018
IPC:
C07K 16/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
TENEOBIO, INC. [US/US]; 1490 O'Brien Drive Suite D Menlo Park, California 94025, US
Inventors:
CLARKE, Starlynn; US
DANG, Kevin; US
ALDRED, Shelley Force; US
TRINKLEIN, Nathan; US
VAN SCHOOTEN, Wim; US
Agent:
PELLETIER, Benjamin C.; US
Priority Data:
62/558,14713.09.2017US
Title (EN) HEAVY CHAIN ANTIBODIES BINDING TO ECTOENZYMES
(FR) ANTICORPS À CHAÎNE LOURDE SE LIANT À DES EXOENZYMES
Abstract:
(EN) Human heavy chain antibodies, such as UniAbsTM, binding to ectoenzymes are provided along with combinations of such heavy chain antibodies and multi-specific heavy chain antibodies, targeting non-overlapping epitopes on ectoenzymes, including synergistic combinations. Methods of making such antibodies, compositions including pharmaceutical compositions comprising such antibodies, and methods directed to the treatment of disease or conditions associated with the expression of ectoenzymes are also included.
(FR) L'invention concerne des anticorps humains à chaîne lourde, tels que UniAbsTM, se liant à des exoenzymes, ainsi que des combinaisons de tels anticorps à chaîne lourde et d'anticorps à chaîne lourde multi-spécifiques, ciblant des épitopes non chevauchants sur des exoenzymes, y compris des combinaisons synergiques. L'invention concerne également des procédés de fabrication de tels anticorps, des compositions notamment des compositions pharmaceutiques comprenant de tels anticorps, et des méthodes de traitement d'une maladie ou d'états pathologiques associés à l'expression d'exoenzymes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)