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1. WO2019055261 - MODIFIED 5'-UNTRANSLATED REGION (UTR) SEQUENCES FOR INCREASED PROTEIN PRODUCTION IN BACILLUS

Publication Number WO/2019/055261
Publication Date 21.03.2019
International Application No. PCT/US2018/049470
International Filing Date 05.09.2018
IPC
C12N 15/75 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
75for Bacillus
CPC
C12N 15/75
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
75for Bacillus
Applicants
  • DANISCO US INC [US]/[US]
Inventors
  • DE LANGE, Dennis
  • FRISCH, Ryan L.
  • MASSON, Helen Olivia
Agents
  • BRAZIL, Bill T.
Priority Data
62/558,30413.09.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MODIFIED 5'-UNTRANSLATED REGION (UTR) SEQUENCES FOR INCREASED PROTEIN PRODUCTION IN BACILLUS
(FR) SÉQUENCES MODIFIÉES DE RÉGION 5' NON TRADUITE (UTR) POUR UNE PRODUCTION ACCRUE DE PROTÉINES DANS BACILLUS
Abstract
(EN)
The present disclosure is generally modified Bacillus strains and host cells thereof capable of producing increased amounts of industrially relevant proteins of interest. Other embodiments of the disclosure are related to isolated polynucleotides comprising modified Bacillus subtilis aprE 5'-untranslated region (5'-UTR) nucleic acid sequences, vectors thereof, DNA (expression) constructs thereof, modified Bacillus (daughter) cells thereof, and methods of making and using the same.
(FR)
La présente invention concerne, de manière générale, des souches de Bacillus modifiées et des cellules hôtes de celles-ci capables de produire des quantités accrues de protéines d'intérêt industriellement pertinentes. D'autres modes de réalisation de l'invention concernent des polynucléotides isolés comprenant des séquences d'acides nucléiques de région 5' non traduite (5'-UTR) de Bacillus subtilis aprE, des vecteurs de celles-ci, des constructions d'ADN (expression) de celles-ci, des cellules (filles) de Bacillus modifiées de celles-ci, et des procédés de fabrication et d'utilisation de celles-ci.
Also published as
JP2020515233
Latest bibliographic data on file with the International Bureau