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1. WO2019054427 - COMPOUND HAVING CYCLIC STRUCTURE

Publication Number WO/2019/054427
Publication Date 21.03.2019
International Application No. PCT/JP2018/033909
International Filing Date 13.09.2018
IPC
C07D 249/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
A61K 31/4196 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41961,2,4-Triazoles
A61K 31/4439 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/454 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/5377 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5377not condensed and containing further heterocyclic rings, e.g. timolol
A61P 1/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
CPC
A61K 31/4196
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41961,2,4-Triazoles
A61K 31/4439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/5377
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5377not condensed and containing further heterocyclic rings, e.g. timolol
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Applicants
  • 第一三共株式会社 DAIICHI SANKYO COMPANY, LIMITED [JP]/[JP]
Inventors
  • 谷口 亨 TANIGUCHI, Toru
  • 岩本 理 IWAMOTO, Osamu
  • 齋藤 啓志 SAITO, Keiji
  • 中島 勝義 NAKAJIMA, Katsuyoshi
  • 小川 泰之 OGAWA, Yasuyuki
  • 栗川 伸也 KURIKAWA, Nobuya
  • 長田 聖子 NAGATA, Seiko
  • 伊藤 香織 ITO, Kaori
  • 來生 江利子 KIOI, Eriko
Agents
  • 石橋 公樹 ISHIBASHI Koki
  • 竹元 利泰 TAKEMOTO Toshiyasu
Priority Data
2017-17689114.09.2017JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) COMPOUND HAVING CYCLIC STRUCTURE
(FR) COMPOSÉ À STRUCTURE CYCLIQUE
(JA) 環状構造を有する化合物
Abstract
(EN)
The present invention addresses the problem of providing a compound having an anti-inflammatory effect, a pharmacologically acceptable salt thereof, etc. The means for solution according to the present invention is a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (The symbols in the formula are defined as follows. A: benzene, etc.; E: -CH2-, etc.; G: a five-membered aromatic heterocycle, etc.; X: cyclohexane, etc.; J: a five-membered aromatic heterocycle, etc.; Y: a phenyl group, etc.; R1, R2, and R3: a halogen atom, etc.; R4: a C1-6 alkyl group, etc.; R5: a hydrogen atom, etc.; R6a, R6b, R6c, and R6d: a hydrogen atom, etc.; R7: a hydrogen atom, etc.; R8: a hydrogen atom, etc.; n1, n2, n3: 1, etc.)
(FR)
Le problème décrit par la présente invention concerne la fourniture d'un composé présentant un effet anti-inflammatoire, un sel acceptable sur le plan pharmacologique de celui-ci, etc. La solution selon la présente invention porte sur un composé représenté par la formule générale (I) ou un sel pharmacologiquement acceptable de celui-ci. (Les symboles dans la formule sont définis comme suit, A : benzène, etc. ; E : -CH2-, etc. ; G : hétérocycle aromatique à cinq chaînons, etc. ; X : cyclohexane, etc. ; J : hétérocycle aromatique à cinq chaînons, etc. ; Y : groupe phényle, etc. ; R1, R2 et R3 : atome d'halogène, etc. ; R4 : groupe alkyle en C1-6, etc. ; R5 : atome d'hydrogène, etc. ; R6a, R6b, R6c et R6d : atome d'hydrogène, etc. ; R7 : atome d'hydrogène, etc. ; R8 : atome d'hydrogène, etc. ; n1, n2, n3 : 1, etc.)
(JA)
本発明の課題は、抗炎症作用を有する化合物、その薬理上許容される塩等を提供すること。 本発明の解決手段は、一般式(1)の化合物又はその薬理上許容される塩。 [式中の記号は以下に定義される。 A:ベンゼン等、E:-CH2-等、G:5員芳香族複素環等、X:シクロヘキサン等、J:5員芳香族複素環等、Y:フェニル基等、R1、R2、R3:ハロゲン原子等、R4:C1-C6アルキル基等、R5:水素原子等、R6a、R6b、R6c、R6d:水素原子等、R7:水素原子等、R8:水素原子等、n1、n2、n3:1等]
Also published as
MXMX/a/2020/002944
RU2020113329
UAa202002357
Latest bibliographic data on file with the International Bureau