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1. WO2019053560 - HIGHLY EFFICIENT ENZYMATIC PROCESS TO PRODUCE (R)-3-QUINUCLIDINOL

Publication Number WO/2019/053560
Publication Date 21.03.2019
International Application No. PCT/IB2018/056767
International Filing Date 05.09.2018
IPC
C12N 9/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
CPC
C07D 453/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
04having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
C12N 9/0006
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
0004Oxidoreductases (1.)
0006acting on CH-OH groups as donors (1.1)
C12P 17/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
12containing a six-membered hetero ring
Applicants
  • UNICHEM LABORATORIES LTD [IN]/[IN]
Inventors
  • D'SOUZA, Conchita
  • ASHOK, Maitreyi
  • UDIPI, Minal P.
  • DAS, Arijit
  • KATDARE, Mamata
  • KUMAR, Sudeep
  • SATHE, Dhananjay
Agents
  • KHURANA & KHURANA ADVOCATES AND IP ATTORNEYS
Priority Data
20172103220212.09.2017IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HIGHLY EFFICIENT ENZYMATIC PROCESS TO PRODUCE (R)-3-QUINUCLIDINOL
(FR) PROCÉDÉ ENZYMATIQUE HAUTEMENT EFFICACE POUR PRODUIRE DU (R)-3-QUINUCLIDINOL
Abstract
(EN)
The present invention relates to enzymatic reduction of 3-quinuclidinone to (R)-3-quinuclidinol (Scheme I), by reacting 3-quinuclidinone with a variant of ketoreductase enzyme derived from Rhodotorula rubra. The invention also relates to enzymatically produced (R)-3-quinuclidinol wherein the substrate loading capacity of the enzyme is not less than 100g/L.
(FR)
La présente invention concerne la réduction enzymatique de 3-quinuclidinone en (R)-3-quinuclidinol (Schéma I), par réaction de 3-quinuclidinone avec une variante d'une enzyme cétoréductase dérivée de Rhodotorula rubra. L'invention concerne également du (R)-3-quinuclidinol produit par voie enzymatique, la capacité de chargement de substrat de l'enzyme n'étant pas inférieure à 100 g/L.
Also published as
JP2020514543
Latest bibliographic data on file with the International Bureau