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1. WO2019052562 - FUSION PROTEIN OF IL-4R AND USE THEREOF

Publication Number WO/2019/052562
Publication Date 21.03.2019
International Application No. PCT/CN2018/106034
International Filing Date 17.09.2018
IPC
A01N 63/00 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
CPC
A01N 63/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
63Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/7155
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
715for cytokines; for lymphokines; for interferons
7155for interleukins [IL]
C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
Applicants
  • 科济生物医药(上海)有限公司 CARSGEN THERAPEUTICS CO., LTD. [CN]/[CN]
  • 上海市肿瘤研究所 SHANGHAI CANCER INSTITUTE [CN]/[CN]
Inventors
  • 李宗海 LI, Zonghai
  • 王益 WANG, Yi
Agents
  • 上海一平知识产权代理有限公司 XU AND PARTNERS, LLC.
Priority Data
201710833528.015.09.2017CN
201810054274.719.01.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) FUSION PROTEIN OF IL-4R AND USE THEREOF
(FR) PROTÉINE DE FUSION D'UNE IL-4R ET SON UTILISATION
(ZH) IL-4R的融合蛋白及其应用
Abstract
(EN)
Provided is an immune effector cell expressing a fusion protein. The fusion protein contains a cytokine binding extracellular domain and a signal transduction intracellular domain, wherein the extracellular domain is the extracellular domain of an IL4 receptor and the intracellular domain is the intracellular domain of an IL-21 receptor. The immune effector cell has a significant anti-tumor ability in the tumor microenvironment of solid tumors, and hence is not only effective against solid tumor cells in vitro, but also has excellent killing effects with regard to solid tumor cells in vivo. Also provided are pharmaceutical compositions containing the immune effector cell and the use thereof.
(FR)
La présente invention concerne une cellule effectrice immunitaire exprimant une protéine de fusion. La protéine de fusion contient un domaine extracellulaire de liaison aux cytokines et un domaine intracellulaire de transduction de signal, le domaine extracellulaire étant le domaine extracellulaire d'un récepteur IL4 et le domaine intracellulaire étant le domaine intracellulaire d'un récepteur IL-21. La cellule effectrice immunitaire présente une capacité anti-tumorale significative dans le micro-environnement tumoral des tumeurs solides, et de là n'est pas seulement efficace contre les cellules tumorales solides in vitro, mais également présente d'excellents effets d'élimination concernant les cellules tumorales solides in vivo. La présente invention concerne également des compositions pharmaceutiques contenant la cellule effectrice immunitaire et son utilisation.
(ZH)
提供表达一种融合蛋白的免疫效应细胞,所述融合蛋白包含细胞因子结合胞外结构域和信号转导胞内结构域,其中所述胞外结构域为IL4受体胞外结构域,所述胞内结构域为IL-21受体胞内结构域。所述免疫效应细胞在实体瘤的肿瘤微环境中具备显著的抗肿瘤能力,从而不仅在体外对实体瘤细胞有效,在体内对实体瘤细胞也具备优异的杀伤效果。还提供包含所述免疫效应细胞的药物组合物以及它们的应用。
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