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1. WO2019052310 - TOTAL FLAVONOIDS EXTRACT OF GYNURA FORMOSANA KITAM., PREPARATION METHOD THEREFOR AND USE THEREOF FOR TREATING HYPERURICEMIA

Publication Number WO/2019/052310
Publication Date 21.03.2019
International Application No. PCT/CN2018/101168
International Filing Date 17.08.2018
IPC
A61K 36/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A61P 19/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
06Antigout agents, e.g. antihyperuricemic or uricosuric agents
A23L 33/105 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A61K 31/7048 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
B01D 15/08 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
CPC
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61K 36/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 19/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
06Antigout agents, e.g. antihyperuricemic or uricosuric agents
B01D 15/08
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
Applicants
  • 漳州片仔癀药业股份有限公司 ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 袁慧君 YUAN, Huijun
  • 殷婷婷 YIN, Tingting
  • 洪绯 HONG, Fei
  • 于娟 YU, Juan
  • 曾金香 ZENG, Jinxiang
  • 王世聪 WANG, Shicong
Agents
  • 成都高远知识产权代理事务所(普通合伙) GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP)
Priority Data
201710841633.918.09.2017CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) TOTAL FLAVONOIDS EXTRACT OF GYNURA FORMOSANA KITAM., PREPARATION METHOD THEREFOR AND USE THEREOF FOR TREATING HYPERURICEMIA
(FR) EXTRAIT DE FLAVONOÏDES TOTAUX DE GYNURA FORMOSANA KITAM. , SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION POUR TRAITER L’HYPERURICÉMIE
(ZH) 一种白凤菜总黄酮提取物及其制备方法与治疗高尿酸血症的用途
Abstract
(EN)
Disclosed is a total flavonoids extract of Gynura formosana Kitam., containing 80%-85% of rutin by weight percent content. The results of pharmacological experiments show that the extract can lower the activity of xanthine oxidase in the liver of a hyperuricemia model mouse and reduce the synthesis of uric acid to a certain degree and has a certain uric acid-lowering effect, and can be used as a potential drug for treating hyperuricemia or gout. The method for preparing the total flavonoids extract of Gynura formosana Kitam. comprises: after an extraction step, selecting a complex enzyme composed of enzymes with a specific composition and a specific ratio for enzymolosis, and further carrying out the step of extracting and concentrating with macroporous resin and isolating and purifying with macroporous resin, so that the HPLC purity of rutin in the resulting total flavonoids extract of Gynura formosana Kitam. reaches 80%-85%.
(FR)
L'invention concerne un extrait de flavonoïdes totaux de Gynura formosana Kitam., ayant une teneur de 80 à 85 % de rutine en pourcentage en poids. Les résultats d'expériences pharmacologiques montrent que l'extrait peut abaisser l'activité de la xanthine oxydase dans le foie dans un modèle murin d'hyperuricémie et réduire la synthèse de l'acide urique dans une certaine mesure et a un certain effet d'abaissement de l'acide urique, et peut par conséquent être utilisé comme médicament potentiel pour le traitement de l'hyperuricémie ou de la goutte. Le procédé de préparation de l'extrait de flavonoïdes totaux de Gynura formosana Kitam. comprend : après une étape d'extraction, le choix d'une enzyme complexe composée d'enzymes ayant une composition spécifique et un rapport spécifique pour l'enzymolose, et la mise en œuvre de l'étape d'extraction et de concentration sur résine macroporeuse et d'isolement et de purification sur résine macroporeuse, de façon que la pureté HPLC de la rutine dans l'extrait de flavonoïdes totaux de Gynura formosana Kitam. obtenu atteigne 80-85 %.
(ZH)
一种白凤菜总黄酮提取物,以重量百分含量计,含有80~85%的芦丁。药效实验结果表明,该提取物可以在一定程度上降低高尿酸血症模型小鼠肝脏内黄嘌呤氧化酶的活性、降低尿酸的合成,具有一定的降尿酸作用,可以作为潜在的治疗高尿酸血症或治疗痛风的药物;所述白凤菜总黄酮提取物的制备方法为,在提取步骤后,通过选择特定组成、特定配比的酶组成的复合酶进行酶解,进一步通过大孔树脂萃取浓缩和大孔树脂分离纯化步骤,使得制备得到的白凤菜总黄酮提取物中芦丁的HPLC纯度可达80~85%。
Also published as
JP2020537273
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