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1. WO2019051181 - NANOSENSOR METHODS AND APPARATUSES FOR DETERMINATION OF ANALYTES

Publication Number WO/2019/051181
Publication Date 14.03.2019
International Application No. PCT/US2018/049883
International Filing Date 07.09.2018
IPC
G01N 21/65 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
65Raman scattering
G01N 33/553 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
551the carrier being inorganic
553Metal or metal coated
CPC
B01L 2200/026
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
02Adapting objects or devices to another
026Fluid interfacing between devices or objects, e.g. connectors, inlet details
B01L 2200/0647
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0647Handling flowable solids, e.g. microscopic beads, cells, particles
B01L 2200/141
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
14Process control and prevention of errors
141Preventing contamination, tampering
B01L 2300/044
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
04Closures and closing means
041Connecting closures to device or container
044pierceable, e.g. films, membranes
B01L 2300/0636
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0627Sensor or part of a sensor is integrated
0636Integrated biosensor, microarrays
B01L 2300/0829
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0809rectangular shaped
0829Multi-well plates; Microtitration plates
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US]
Inventors
  • QUAN, Qimin
  • LIANG, Feng
Agents
  • CHEN, Tani
Priority Data
62/556,18608.09.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NANOSENSOR METHODS AND APPARATUSES FOR DETERMINATION OF ANALYTES
(FR) PROCÉDÉS ET APPAREILS À BASE DE NANOCAPTEURS POUR LA DÉTERMINATION D'ANALYTES
Abstract
(EN)
The present invention generally relates to nanosensors for determination of molecules and other features, e.g., via surface plasmonic resonance, electric resonance, magnetic resonance, color changes, or the like. These articles and methods may be used, for example, for sample detection. The articles described in some aspects of the invention include a microwell array and a nanosensor array. The nanosensor arrays may utilize nanoparticles positioned on nanostructures that are able to interact with a sample suspected of containing an analyte, such as a single cell. The interaction between nanoparticles and a sample can be detected by a change in applied energy, such as altered electromagnetic ladialiun caused by surface plasmonic resonance of incident visible light, and/or other types of resonance. Electromagnetic radiation may be applied to a microwell array and nanosensor, and the applied electromagnetic radiation may be altered as a nanosensor interacts with a sample suspected of containing an analyte.
(FR)
Dans certains aspects, la présente invention concerne d'une manière générale des articles et des procédés se rapportant à des nanocapteurs pour la détermination de molécules et autres caractéristiques, par exemple par résonance plasmonique de surface, résonance électrique, résonance magnétique, changements de couleur, ou analogues. Ces articles et procédés peuvent être utilisés, par exemple, pour la détection d'échantillons. Les articles décrits dans certains aspects de l'invention comprennent un réseau de micropuits et un réseau de nanocapteurs. Dans certains modes de réalisation, les réseaux de nanocapteurs peuvent utiliser des nanoparticules positionnées sur des nanostructures qui sont capables d'interagir avec un échantillon suspecté de contenir un analyte, tel qu'une seule cellule. L'interaction entre des nanoparticules et un échantillon peut être détectée par un changement d'énergie appliquée, tel qu'un rayonnement électromagnétique modifié provoqué par une résonance plasmonique de surface de la lumière visible incidente, et/ou d'autres types de résonance. Un rayonnement électromagnétique peut être appliqué sur un réseau de micropuits et sur un nanocapteur, et le rayonnement électromagnétique appliqué peut être modifié alors qu'un nanocapteur interagit avec un échantillon suspecté de contenir un analyte. De plus, dans certains modes de réalisation, les réseaux de nanocapteurs peuvent utiliser des nanostructures et la liaison d'analytes peut être déterminée sur la base de changements optiques ou de couleur.
Also published as
JP2020513860
Latest bibliographic data on file with the International Bureau