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1. (WO2019050850) BIGUANIDINE DERIVATIVES OF THERAPEUTIC AGENTS AND METHODS OF PREPARATION AND USE THEREOF
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Pub. No.: WO/2019/050850 International Application No.: PCT/US2018/049382
Publication Date: 14.03.2019 International Filing Date: 04.09.2018
IPC:
A61K 31/155 (2006.01) ,A61K 31/335 (2006.01) ,A61K 31/506 (2006.01) ,A61K 47/55 (2017.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
[IPC code unknown for A61K 47/55]
Applicants:
PRIMETIME LIFE SCIENCES, LLC [US/US]; 13628 Monarch Vista Drive Germantown, MD 20874, US
Inventors:
JANAK, Khimchand Padia; US
Priority Data:
62/554,04605.09.2017US
Title (EN) BIGUANIDINE DERIVATIVES OF THERAPEUTIC AGENTS AND METHODS OF PREPARATION AND USE THEREOF
(FR) DÉRIVÉS BIGUANIDINE D'AGENTS THÉRAPEUTIQUES, ET PROCÉDÉS DE PRÉPARATION ET MÉTHODES D'UTILISATION CORRESPONDANTS
Abstract:
(EN) The invention includes biguanidine derivatives of therapeutic agents of Formula IA or Formula IB including pharmaceutically acceptable, prodrugs, metabolites and isomers thereof. The invention also provides methods of preparation and use of these compounds for treating and/or preventing a wide variety of disease conditions and disorders. The invention also includes pharmaceutical compositions, preparation of prodrugs, and mutual prodrugs comprised of the constituent compounds of Formula IA, Formula IB Formula IC and Formula ID.
(FR) L'invention concerne des dérivés biguanidine d'agents thérapeutiques de formule IA ou de formule IB, y compris des promédicaments, métabolites et isomères pharmaceutiquement acceptables correspondants. L'invention concerne également des procédés de préparation et des méthodes d'utilisation de ces composés en vue de traiter et/ou de prévenir une grande variété d'états et troubles pathologiques. L'invention concerne également des compositions pharmaceutiques, la préparation de promédicaments, et des promédicaments mutuels constitués des composés constitutifs de formule IA, formule IB, formule IC et formule ID.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)