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1. (WO2019050479) HYGROSCOPIC, CROSSLINKING COATINGS AND BIOADHESIVES
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Pub. No.: WO/2019/050479 International Application No.: PCT/SG2018/050452
Publication Date: 14.03.2019 International Filing Date: 06.09.2018
IPC:
A61L 24/04 (2006.01) ,A61L 26/00 (2006.01) ,C08G 63/08 (2006.01) ,C08G 83/00 (2006.01) ,C08L 67/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24
Surgical adhesives or cements; Adhesives for colostomy devices
04
containing macromolecular materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
26
Chemical aspects of, or use of materials for, liquid bandages
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
63
Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
02
Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds
06
derived from hydroxy carboxylic acids
08
Lactones or lactides
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
83
Macromolecular compounds not provided for in groups C08G2/-C08G81/104
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
L
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
67
Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
04
Polyesters derived from hydroxy carboxylic acids, e.g. lactones
Applicants:
NANYANG TECHNOLOGICAL UNIVERSITY [SG/SG]; 50 Nanyang Avenue Singapore 639798, SG
Inventors:
STEELE, Terry W. J.; SG
DJORDJEVIC, Ivan; SG
Agent:
VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Post Office, Rochor Road Singapore 911833, SG
Priority Data:
10201707244R06.09.2017SG
Title (EN) HYGROSCOPIC, CROSSLINKING COATINGS AND BIOADHESIVES
(FR) REVÊTEMENTS ET BIOADHÉSIFS DE RÉTICULATION HYGROSCOPIQUE
Abstract:
(EN) According to the present disclosure, a bioadhesive formulation is provided. The bioadhesive formulation comprises a polycaprolactone dendrimer having a dendrimer core and a plurality of polycaprolactone chains extending from the dendrimer core, wherein at least one of the polycaprolactone chains has an end which is covalently attached with a diazirine, and wherein the diazirine converts to a carbene or a diazoalkyl when a stimulant is applied to the bioadhesive formulation. Methods of forming the bioadhesive formulation are also provided. The bioadhesive could be used in (i) the prevention of thrombosis from tissue fixation and/or (ii) the relief of discomfort and/or pain during and/or after surgery. Preferably, the bioadhesive formulation further comprises a hygroscopic additive, an antithrombotic agent, and/or an anaesthetic agent.
(FR) La présente invention concerne une formulation bioadhésive. La formulation bioadhésive comprend un dendrimère polycaprolactone ayant un cœur de dendrimère et une pluralité de chaînes de polycaprolactone s'étendant à partir du cœur de dendrimère, au moins l'une des chaînes de polycaprolactone ayant une extrémité qui est attachée de manière covalente à une diazirine, et la diazirine convertissant en un carbène ou un diazoalkyle lorsqu'un stimulant est appliqué à la formulation bioadhésive. L'invention concerne également des procédés de formation de la formulation bioadhésive. La formulation bioadhésive peut être utilisée dans (i) la prévention de la thrombose à partir de la fixation tissulaire et/ou (ii) le soulagement de l'inconfort et/ou de la douleur pendant et/ou après une chirurgie. De préférence, la formulation bioadhésive comprend en outre un additif hygroscopique, un agent antithrombotique et/ou un agent anesthésique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)