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1. (WO2019050362) ANTIBODY AGAINST HUMAN DLK1 AND USE THEREOF
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Pub. No.: WO/2019/050362 International Application No.: PCT/KR2018/010559
Publication Date: 14.03.2019 International Filing Date: 10.09.2018
IPC:
C07K 16/28 (2006.01) ,C07K 14/725 (2006.01) ,A61K 47/68 (2017.01) ,C12N 5/0783 (2010.01) ,G01N 33/574 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
[IPC code unknown for A61K 47/68]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
주식회사 와이바이오로직스 Y-BIOLOGICS INC. [KR/KR]; 대전시 유성구 테크노4로 29 3층 3F. 29, Techno 4-ro Yuseong-gu Daejeon 34015, KR
Inventors:
임정채 LIM, Jung Chae; KR
신지영 SHIN, Ji-Young; KR
윤선하 YOON, Sunha; KR
이상필 LEE, Sang Pil; KR
최윤선 CHOI, Yunseon; KR
이지수 LEE, Jisu; KR
조영규 CHO, Young-Gyu; KR
유석호 YOO, Seok Ho; KR
김응철 KIM, Yeung chul; KR
이시형 LEE, Si Hyung; KR
박재은 PARK, Jae Eun; KR
송영자 SONG, Youngja; KR
백기선 BAEK, Gi Sun; KR
박범찬 PARK, Bum-chan; KR
박영우 PARK, Young Woo; KR
Agent:
이처영 LEE, Cheo Young; KR
장제환 CHANG, Je Hwan; KR
Priority Data:
10-2017-011526308.09.2017KR
Title (EN) ANTIBODY AGAINST HUMAN DLK1 AND USE THEREOF
(FR) ANTICORPS DIRIGÉ CONTRE DLK1 HUMAIN ET UTILISATION ASSOCIÉE
(KO) 인간 DLK1에 대한 항체 및 이의 용도
Abstract:
(EN) The present invention relates to an antibody against delta-like 1 homolog (Drosophila) (DLK1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a method for producing the antibody or an antigen-binding fragment thereof, an antibody drug conjugate (ADC) comprising the same, a pharmaceutical composition for treating cancer, a composition for diagnosing cancer, and a chimeric antigen receptor (CAR) and a T-cell engager comprising the same.
(FR) La présente invention concerne un anticorps contre DLK1 (delta-like 1 homolog (Drosophila) ou un fragment de liaison à l'antigène de celui-ci, un acide nucléique codant pour celui-ci, un vecteur comprenant l'acide nucléique, une cellule transformée avec le vecteur, un procédé de production de l'anticorps ou d'un fragment de liaison à l'antigène de celui-ci, un conjugué anticorps-médicament (ADC) comprenant celui-ci, une composition pharmaceutique pour le traitement du cancer, une composition pour le diagnostic du cancer, et un récepteur d'antigène chimère (CAR) et un anticorps engageant les lymphocytes T le comprenant.
(KO) 본 발명은 DLK1(delta-like 1 homolog (Drosophila))에 대한 항체 또는 이의 항원 결합 단편, 이를 코딩하는 핵산, 상기 핵산을 포함하는 벡터, 상기 벡터로 형질전환된 세포, 상기 항체 또는 그의 항원 결합 단편의 제조방법, 이를 포함하는 항체-약물 접합체(Antibody drug conjugate: ADC), 암 치료용 약학 조성물, 암 진단용 조성물, 이를 포함하는 키메라 항원 수용체(Chimeric antigen receptor: CAR) 및 T 세포 관여자(T-cell engager)에 관한 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)