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1. (WO2019050326) COMPOSITION FOR RESTRAINING ACTIVITY OF REGULATORY T CELL, COMPRISING PEPTIDE BINDING SPECIFICALLY TO NEUROPILIN 1 (NRP1)
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Pub. No.: WO/2019/050326 International Application No.: PCT/KR2018/010487
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C07K 7/08 (2006.01) ,A61K 45/06 (2006.01) ,A61K 47/68 (2017.01) ,A61K 38/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
[IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
아주대학교산학협력단 AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 경기도 수원시 영통구 월드컵로 206 206, World cup-ro, Yeongtong-gu Suwon-si Gyeonggi-do 16499, KR
Inventors:
김용성 KIM, Yong Sung; KR
김예진 KIM, Ye Jin; KR
정근옥 JUNG, Keunok; KR
김정아 KIM, Jeong-Ah; KR
Agent:
이처영 LEE, Cheo Young; KR
장제환 CHANG, Je Hwan; KR
Priority Data:
10-2017-011526208.09.2017KR
Title (EN) COMPOSITION FOR RESTRAINING ACTIVITY OF REGULATORY T CELL, COMPRISING PEPTIDE BINDING SPECIFICALLY TO NEUROPILIN 1 (NRP1)
(FR) COMPOSITION LIMITANT L'ACTIVITÉ D'UN LYMPHOCYTE T RÉGULATEUR, COMPRENANT UNE LIAISON PEPTIDIQUE SPÉCIFIQUE À LA NEUROPILINE 1 (NRP1)
(KO) 뉴로필린 1 (NEUROPILIN 1, NRP1)에 특이적으로 결합하는 펩타이드를 포함하는 조절 T 세포의 활성을 억제하기 위한 조성물
Abstract:
(EN) The present invention relates to a composition for inhibiting the immunosuppression of regulatory T cells (Treg), using a fusion protein inclusive of a peptide binding specifically to neuropilin 1 (NRP1). A fusion protein inclusive of a peptide binding specifically to neuropilin 1 according to the present invention reduces a proportion of regulatory T cells of CD4+ T cells in a tumor tissue and restrains the activity of regulatory T cells that have penetrated into a tumor tissue, thereby downregulating the immunosuppression in the tumor tissue without systemic toxicity and thus can be expected to exert a high therapeutic effect on a tumor.
(FR) La présente invention concerne une composition permettant d'inhiber l'immunosuppression de lymphocytes T régulateurs (Treg), à l'aide d'une protéine de fusion incluant un peptide se liant de manière spécifique à la neuropiline 1 (NRP1). La protéine de fusion incluant un peptide se liant de manière spécifique à la neuropiline 1 fournie par la présente invention réduit une proportion de lymphocytes T régulateurs de lymphocytes T CD4+ dans un tissu tumoral et limite l'activité de lymphocytes T régulateurs qui ont pénétré dans un tissu tumoral, ce qui permet de réduire l'immunosuppression dans le tissu tumoral sans toxicité systémique et peut donc être susceptible d'exercer un effet thérapeutique élevé sur une tumeur.
(KO) 본 발명은 뉴로필린 1(Neuropilin 1, NRP1)에 특이적으로 결합하는 펩타이드를 포함하는 융합 단백질을 이용한 조절 T 세포(Regulatory T cell, Treg)의 면역반응 억제 저해용 조성물에 관한 것이다. 본 발명에 따른 뉴로필린 1에 특이적으로 결합하는 펩타이드를 포함하는 융합 단백질은 종양 조직 내에서 CD4+ T 세포 중 조절 T 세포의 비율을 감소시키고, 종양 조직 내 침투해 있는 조절 T 세포의 활성을 억제함으로써, 전신에 대한 독성 없이 종양조직 내에서 면역억제 반응을 하향 조절할 수 있는 바, 종양의 치료에 높은 효과를 기대할 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)