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1. (WO2019050071) COMPOSITION FOR PREVENTING OR TREATING LIVER FIBROSIS, CONTAINING EXOSOME OR EXOSOME-DERIVED RIBONUCLEIC ACID
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Pub. No.: WO/2019/050071 International Application No.: PCT/KR2017/009910
Publication Date: 14.03.2019 International Filing Date: 08.09.2017
IPC:
A61K 35/28 (2006.01) ,A61K 35/407 (2006.01) ,A61K 48/00 (2006.01) ,A23L 33/10 (2016.01) ,A23L 33/13 (2016.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
37
Digestive system
407
Liver
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
[IPC code unknown for A23L 33/10][IPC code unknown for A23L 33/13]
Applicants:
고려대학교 산학협력단 KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION [KR/KR]; 서울시 성북구 안암로 145 145, Anam-ro Seongbuk-gu Seoul 02841, KR
Inventors:
홍재상 HONG, Jae Sang; KR
이도훈 LEE, Do Hoon; KR
장유진 JANG, Yu Jin; KR
김종훈 KIM, Jong Hoon; KR
이영식 LEE, Young Sik; KR
Agent:
김순웅 KIM, Soon Woong; KR
Priority Data:
Title (EN) COMPOSITION FOR PREVENTING OR TREATING LIVER FIBROSIS, CONTAINING EXOSOME OR EXOSOME-DERIVED RIBONUCLEIC ACID
(FR) COMPOSITION DESTINÉE À LA PRÉVENTION OU AU TRAITEMENT DE LA FIBROSE HÉPATIQUE, CONTENANT UN EXOSOME OU UN ACIDE RIBONUCLÉIQUE DÉRIVÉ D'EXOSOME
(KO) 엑소좀 또는 엑소좀 유래 리보핵산을 포함하는 간섬유증 예방 또는 치료용 조성물
Abstract:
(EN) The present invention relates to a composition or a cell therapeutic agent for preventing or treating liver fibrosis, containing an exosome or exosome-derived ribonucleic acid. The exosome or ribonucleic acid derived therefrom, of the present invention, has effects of inhibiting activities of hepatic stellate cells and Kupffer cells and reducing the expression of α-SMA and inhibits the progression of liver fibrosis by inhibiting the deposition of collagen, thereby being effectively usable as a cell therapeutic agent for the prevention or treatment of liver fibrosis.
(FR) La présente invention concerne une composition ou un agent thérapeutique cellulaire pour prévenir ou traiter la fibrose hépatique, contenant un exosome ou un acide ribonucléique dérivé d'exosome. L'exosome ou l'acide ribonucléique dérivé de ce dernier, qui font l'objet de la présente invention, ont comme effets d'inhiber les activités des cellules stellaires hépatiques et des cellules de Kupffer et de diminuer l'expression de l'α-SMA, et inhibent la progression de la fibrose hépatique en inhibant le dépôt du collagène, étant de ce fait utilisables de façon efficace en tant qu'agents thérapeutiques cellulaires pour la prévention ou le traitement de la fibrose hépatique.
(KO) 본 발명은 엑소좀 또는 엑소좀 유래 리보핵산을 포함하는 간섬유증 예방 또는 치료용 조성물 또는 세포치료제에 관한 것이다. 본 발명의 엑소좀 및 이로부터 유래된 리보핵산은 간성상세포 및 쿠퍼세포의 활성을 억제하고 α-SMA의 발현을 감소시키는 효과가 있으며, 교원질의 침착을 억제하여 간섬유증의 진행을 억제시킴으로써 간섬유증의 예방이나 치료에 있어서 세포치료제로 유용하게 이용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)